Development of a CMOS-compatible PCR chip: Comparison of design and system strategies

Ivan Erill, Susana Campoy, José Rus, Luis Fonseca, Antoni Ivorra, Zenón Navarro, José A. Plaza, Jordi Aguiló, Jordi Barbé

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)


The development of a line of polymerase chain reaction (PCR) chips that was fully compatible with complementary-metal-oxide-semiconductor (CMOS) technology was discussed. The CMOS technology can be used as a general platform to test and compare a wide range of experimental parameters involved in PCR-chip design and operation. The developed PCR-chip platform has been used as a common reference ground to conduct the first fully-fledged analysis of many different PCR-chip design and strategies. The results show that the CMOS-compatible processes enables a fast and easy adaption to foundary requirements and for a scalable integration of electro-optic detection and control circuitry.
Original languageEnglish
Pages (from-to)1558-1568
JournalJournal of Micromechanics and Microengineering
Publication statusPublished - 1 Nov 2004


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