Development and validation of the Crohn's disease perceived work disability questionnaire

Mercedes Vergara, Antonia Montserrat, Francesc Casellas, Olga Gallardo, David Suarez, Jaume Motos, Albert Villoria, Mireia Miquel, Eva Martinez-Bauer, Xavier Calvet

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19 Citations (Scopus)


Background: No validated instruments have been developed to measure work disability in Crohn's disease (CD). The aim of our study was to develop and validate a CD perceived work disability questionnaire (CPWDQ). Methods: Development phase: an initial questionnaire containing 52 items was obtained from patients' interviews plus additional sources; it was completed by 106 patients and the 16 most significant items were selected using a psychometric method in order to create the CPWDQ. Validation phase: The validation assessed the questionnaire's convergent validity, discriminant validity, test-retest reproducibility, and internal consistency in 108 patients. Spearman rank correlation, t-test, intraclass correlation, and Cronbach's alpha were used for the analysis. Results: Convergent validity was confirmed by good correlations between the CPWDQ and: clinical activity (r = 0.59, P < 0.01), the Short Inflammatory Bowel Disease Questionnaire, IBDQ-9, (r = 0.76, P < 0.001), Euroqol-5D (r = 0.53, P < 0.01), and overall work impairment (WPAI-CD) r = 0.66 (P < 0.01). Discriminant validity: CPWQ scores were higher in patients expected to have more severe disability, that is, in patients with active disease (n = 38) 32.3 ± 7.3 versus inactive (n = 70) 22.6 ± 5.9 (P < 0.001), in those requiring previous sick leave 30.7 ± 7.5 (n = 45) versus no sick leave 22.6 ± 6.6 (n = 63) (P < 0.01), and in those requiring hospitalization 32.2 ± 8.6 (n = 18) versus no hospitalization 24.7 ± 7.1 (n = 90) (P < 0.01). Internal consistency was also good (Cronbach's alpha = 0.89). Reproducibility: CPWDQ measures obtained 2 weeks apart showed an excellent intraclass correlation coefficient: 0.89 (95% CI: 0.83-0.93). Conclusions: The CPWDQ seems to be a valid, reliable tool for measuring subjective work disability in CD. Copyright © 2011 Crohn's & Colitis Foundation of America, Inc.
Original languageEnglish
Pages (from-to)2350-2357
JournalInflammatory Bowel Diseases
Publication statusPublished - 1 Nov 2011


  • Crohn's disease
  • inflammatory bowel disease
  • quality of life
  • work disability


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