Development and validation of an alternative version of the Parkinson's Disease-Cognitive Rating Scale (PD-CRS)

Ramón Fernández-Bobadilla, Saül Martínez-Horta, Juan Marín-Lahoz, Andrea Horta-Barba, Javier Pagonabarraga, Jaime Kulisevsky

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

© 2017 Introduction The Parkinson's Disease-Cognitive Rating Scale (PD-CRS) is a valid and reliable instrument to screen for and diagnose mild cognitive impairment in PD (PD-MCI) and to monitor potential outcomes in clinical trials. Although this scale shows adequate sensitivity to change in non-demented PD patients, an alternative form (AF) with proven reliability could minimize practice effects associated with repeated testing. Methods We selected PD-CRS/AF items following the criteria proposed in the original PD-CRS. We assessed a prospective sample of 75 non-demented PD patients (normal cognition, n = 50; PD-MCI, n = 25) using both tools, administered on two consecutive days, in a randomized order. Results The PD-CRS/AF showed a high internal consistency (Cronbach's α = 0.80). Differences between total mean scores were not significant. Floor/ceiling effects were acceptable. The discriminative power for MCI was high for both tools (area under the curve 0.91; 95% CI, 0.84–0.98 for PD-CRS; 0.88, 95% CI, 0.80–0.96 for PD-CRS/AF). Receiver operating curve analysis showed the optimal cut-off point of the two versions to discriminate PD-MCI from PD-normal cognition was ≤81 (PD-CRS = sensitivity 94%, specificity 73%; PD-CRS/AF = sensitivity 92%, specificity 73%). Conclusions Our results suggest that the PD-CRS/AF is a valid and reliable instrument to complement the original PD-CRS as an analogous tool for serial cognitive testing for PD patients in clinical practice and cognitive trials.
Original languageEnglish
Pages (from-to)73-77
JournalParkinsonism and Related Disorders
Volume43
DOIs
Publication statusPublished - 1 Oct 2017

Keywords

  • Alternate form
  • Mild cognitive impairment
  • PD-CRS
  • Parkinson's disease
  • Reliability

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