© 2013 Asociación Española de Pediatría. Publicado por Elsevier España, S.L.U. Todos los derechos reservados. Sputum eosinophils and exhaled fractional nitric oxide (FENO) are markers of air-way inflammation in asthma. Cytokines, cysteinyl-leukotrienes and leukotriene B4(LTB4) areresponsible for this inflammation.The aim of this study is to determine the usefulness of these markers in monitoring asthmatreatment in children. FENO, sputum eosinophils, and LTB4in induced sputum were performed in 10 children (9-15 years old). These determinations were repeated four months later, after the beginning oran increase in the treatment. FENO values tended to decrease (P=.15), pulmonary functiontended to improve (P=.10), and sputum eosinophils decreased (P=.003) compared to the firstdetermination. There were no differences in LTB4concentrations (P=.88).Sputum eosinophils seem to be more precise than FENO in the monitoring of inflammation inasthmatic children.
- Exhaled fractionalnitric oxide
- Leukotriene B 4
- Sputum eosinophils
Vizmanos-Lamotte, G., Cruz, M. J., Gómez-Ollés, S., Muñoz, X., De Mir Messa, I., & Moreno-Galdó, A. (2014). Determining asthma treatment in children by monitoring fractional exhaled nitricoxide, sputum eosinophils and leukotriene B<inf>4</inf> Anales de Pediatria, 82(1), e21-e25. https://doi.org/10.1016/j.anpedi.2014.03.012