Determining asthma treatment in children by monitoring fractional exhaled nitricoxide, sputum eosinophils and leukotriene B<inf>4</inf>

G. Vizmanos-Lamotte, M. J. Cruz, S. Gómez-Ollés, X. Muñoz, I. De Mir Messa, A. Moreno-Galdó

Research output: Contribution to journalArticleResearchpeer-review

Abstract

© 2013 Asociación Española de Pediatría. Publicado por Elsevier España, S.L.U. Todos los derechos reservados. Sputum eosinophils and exhaled fractional nitric oxide (FENO) are markers of air-way inflammation in asthma. Cytokines, cysteinyl-leukotrienes and leukotriene B4(LTB4) areresponsible for this inflammation.The aim of this study is to determine the usefulness of these markers in monitoring asthmatreatment in children. FENO, sputum eosinophils, and LTB4in induced sputum were performed in 10 children (9-15 years old). These determinations were repeated four months later, after the beginning oran increase in the treatment. FENO values tended to decrease (P=.15), pulmonary functiontended to improve (P=.10), and sputum eosinophils decreased (P=.003) compared to the firstdetermination. There were no differences in LTB4concentrations (P=.88).Sputum eosinophils seem to be more precise than FENO in the monitoring of inflammation inasthmatic children.
Original languageEnglish
Pages (from-to)e21-e25
JournalAnales de Pediatria
Volume82
Issue number1
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • Asthma
  • Children
  • Exhaled fractionalnitric oxide
  • Leukotriene B 4
  • Sputum eosinophils

Fingerprint Dive into the research topics of 'Determining asthma treatment in children by monitoring fractional exhaled nitricoxide, sputum eosinophils and leukotriene B<inf>4</inf>'. Together they form a unique fingerprint.

  • Cite this