Abstract
Near infrared diffuse reflectance spectroscopy with a fibre-optic probe was used to determine the water content in ferrous lactate dihydrate. Spectra were recorded by immersing the probe in a beaker containing the ferrous lactate sample. Spectral data were processed by using two different multivariate calibration procedures, viz. stepwise multiple linear regression (SMLR) and partial least-squares regression (PLSR). The results provided by the two calibration procedures were similar and departed by less than 1.5% from the values obtained by Karl Fischer titration.
Original language | English |
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Pages (from-to) | 255-262 |
Journal | Journal of Pharmaceutical and Biomedical Analysis |
Volume | 16 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Oct 1997 |
Keywords
- Fiber-optics
- Multivariate calibration
- Near infrared reflectance spectroscopy
- Pharmaceutical preparations
- Water determination