Determination of tylosin residues in different animal tissues by high performance liquid chromatography

C. Prats, R. Francesch, M. Arboix, B. Pérez

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Abstract

A HPLC method to determine and quantify tylosin residues from calves, pigs and poultry is reported. This procedure permitted tylosin to be separated from muscle, liver, kidney and fat after a simple extraction with chloroform or ethyl acetate under basic conditions. The analytical methodology showed a high specificity and sensitivity and an adequate precision and accuracy with a limit of quantification of 50 μg/kg. Eight calves were administered 20 mg/kg/day of tylosin for 5 days and slaughtered at 7 and 14 days post-administration. Results showed that at the 14th day tylosin levels were lower than the MRL in all target tissues. © 2002 Elsevier Science B.V. All rights reserved.
Original languageEnglish
Pages (from-to)57-65
JournalJournal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Volume766
DOIs
Publication statusPublished - 1 Jan 2002

Keywords

  • Tylosin

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