Determination of ascorbic acid in pharmaceutical preparations by near infrared reflectance spectroscopy

M. Blanco, J. Coello, H. Iturriaga, S. Maspoch, C. de la Pezuela

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29 Citations (Scopus)

Abstract

We developed a method for determination of ascorbic acid in pharmaceutical preparations containing various excipients by using near infrared diffuse reflectance spectroscopy and two different calibration methods, viz. stepwise multiple linear regression (SMLR) and partial least-squares (PLS) regression, which provided comparable results and resulted in prediction errors of 1-2%. However, the PLS method provided somewhat better results with the more complex samples. © 1993.
Original languageEnglish
Pages (from-to)1671-1676
JournalTalanta
Volume40
Issue number11
DOIs
Publication statusPublished - 1 Jan 1993

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