Detection of circulating cancer cells using electrocatalytic gold nanoparticles

Marisa Maltez-Da Costa, Alfredo De La Escosura-Muñiz, Carme Nogués, Lleonard Barrios, Elena Ibáñez, Arben Merkoçi

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Abstract

A rapid cancer cell detection and quantification assay, based on the electrocatalytic properties of gold nanoparticles towards the hydrogen evolution reaction, is described. The selective labeling of cancer cells is performed in suspension, allowing a fast interaction between the gold nanoparticle labels and the target proteins expressed at the cell membrane. The subsequent electrochemical detection is accomplished with small volumes of sample and user-friendly equipment through a simple electrochemical method that generates a fast electrochemical response used for the quantification of nanoparticle-labeled cancer cells. The system establishes a selective cell-detection assay capable of detecting 4 × 103 cancer cells in suspension that can be extended to several other cells detection scenarios. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Original languageEnglish
Pages (from-to)3605-3612
JournalSmall
Volume8
DOIs
Publication statusPublished - 7 Dec 2012

Keywords

  • cancer diagnosis
  • circulating cancer cells
  • electrocatalytic properties
  • gold nanoparticles
  • hydrogen evolution reaction

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