Detection of a sexually transmitted hepatitis C virus protease inhibitor-resistance variant in a human immunodeficiency virus-infected homosexual man

Sandra Franco; Cristina Tural; Maria Nevot; José Moltó; Jürgen Kurt Rockstroh; Bonaventura Clotet; Miguel Angel Martinez

doi:10.1053/j.gastro.2014.05.010

Detection of a sexually transmitted hepatitis C virus protease inhibitor-resistance variant in a human immunodeficiency virus-infected homosexual man

Sandra Franco, Cristina Tural, Maria Nevot, José Moltó, Jürgen Kurt Rockstroh, Bonaventura Clotet, Miguel Angel Martinez

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

44 Citations (Scopus)

Abstract

There is an international epidemic of hepatitis C virus (HCV) infection among human immunodeficiency virus-infected men who have sex with men. Transmission of HCV variants that are resistant to recently approved direct-acting antivirals (DAAs) could be an important clinical and public health problem. We document a case of transmission of a DAA-resistant variant of HCV from a patient who was treated with telaprevir to his sexual partner. The transmission of HCV DAA-resistant variants could impair therapeutic regimens that include DAAs. © 2014 by the AGA Institute.

Original language	English
Journal	Gastroenterology
Volume	147
Issue number	3
DOIs	https://doi.org/10.1053/j.gastro.2014.05.010
Publication status	Published - 1 Jan 2014

Keywords

Cirrhosis
Liver Disease
Transmission

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title = "Detection of a sexually transmitted hepatitis C virus protease inhibitor-resistance variant in a human immunodeficiency virus-infected homosexual man",

abstract = "There is an international epidemic of hepatitis C virus (HCV) infection among human immunodeficiency virus-infected men who have sex with men. Transmission of HCV variants that are resistant to recently approved direct-acting antivirals (DAAs) could be an important clinical and public health problem. We document a case of transmission of a DAA-resistant variant of HCV from a patient who was treated with telaprevir to his sexual partner. The transmission of HCV DAA-resistant variants could impair therapeutic regimens that include DAAs. {\textcopyright} 2014 by the AGA Institute.",

keywords = "Cirrhosis, Liver Disease, Transmission",

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year = "2014",

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Detection of a sexually transmitted hepatitis C virus protease inhibitor-resistance variant in a human immunodeficiency virus-infected homosexual man. / Franco, Sandra; Tural, Cristina; Nevot, Maria; Moltó, José; Rockstroh, Jürgen Kurt; Clotet, Bonaventura; Martinez, Miguel Angel.

In: Gastroenterology, Vol. 147, No. 3, 01.01.2014.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Detection of a sexually transmitted hepatitis C virus protease inhibitor-resistance variant in a human immunodeficiency virus-infected homosexual man

AU - Franco, Sandra

AU - Tural, Cristina

AU - Nevot, Maria

AU - Moltó, José

AU - Rockstroh, Jürgen Kurt

AU - Clotet, Bonaventura

AU - Martinez, Miguel Angel

PY - 2014/1/1

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AB - There is an international epidemic of hepatitis C virus (HCV) infection among human immunodeficiency virus-infected men who have sex with men. Transmission of HCV variants that are resistant to recently approved direct-acting antivirals (DAAs) could be an important clinical and public health problem. We document a case of transmission of a DAA-resistant variant of HCV from a patient who was treated with telaprevir to his sexual partner. The transmission of HCV DAA-resistant variants could impair therapeutic regimens that include DAAs. © 2014 by the AGA Institute.

KW - Cirrhosis

KW - Liver Disease

KW - Transmission

U2 - 10.1053/j.gastro.2014.05.010

DO - 10.1053/j.gastro.2014.05.010

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