Detection of a sexually transmitted hepatitis C virus protease inhibitor-resistance variant in a human immunodeficiency virus-infected homosexual man

Sandra Franco, Cristina Tural, Maria Nevot, José Moltó, Jürgen Kurt Rockstroh, Bonaventura Clotet, Miguel Angel Martinez

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Abstract

There is an international epidemic of hepatitis C virus (HCV) infection among human immunodeficiency virus-infected men who have sex with men. Transmission of HCV variants that are resistant to recently approved direct-acting antivirals (DAAs) could be an important clinical and public health problem. We document a case of transmission of a DAA-resistant variant of HCV from a patient who was treated with telaprevir to his sexual partner. The transmission of HCV DAA-resistant variants could impair therapeutic regimens that include DAAs. © 2014 by the AGA Institute.
Original languageEnglish
JournalGastroenterology
Volume147
Issue number3
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • Cirrhosis
  • Liver Disease
  • Transmission

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