Abstract
Based on a computational model for 5-HT1AR-ligand interaction and QSAR studies, we have designed and synthesized a new series of arylpiperazines 2-8 which exhibit high 5-HT1AR affinity and selectivity over α1-adrenergic receptors. Among them, compound CSP-2503 (4) has been pharmacologically characterized as a 5-HT1AR agonist at somatodendritic and postsynaptic sites, endowed with anxiolytic properties. © 2003 Elsevier Science Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 1429-1432 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 13 |
Issue number | 8 |
DOIs | |
Publication status | Published - 17 Apr 2003 |