Design and patient characteristics of ESHOL study, a Catalonian prospective randomized study

F. Maduell, F. Moreso, M. Pons, R. Ramos, J. Mora-Macià, A. Foraster, J. Soler, J.M. Galceran, A. Martinez-Castelao, Ferran Torres

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)


Background: Retrospective studies showed that online hemodiafiltration (OL-HDF) is associated with a risk reduction of mortality over standard hemodialysis (HD) in patients with end-stage renal disease. Until now, no information was available from prospective randomized clinical trials. Methods: A prospective, randomized, multicenter, open study was designed to be conducted in HD units from Catalonia (Spain). The aim of the study is to compare 3-year survival in prevalent end-stage renal disease patients randomized to OL-HDF or to continue on standard HD. The minimum sample size was calculated according to Catalonian mortality of patients on dialysis and assuming a risk reduction associated with OL-HDF of 35% (1-sided p
Original languageEnglish
Pages (from-to)196-202
Number of pages7
JournalJournal of Nephrology
Issue number2
Publication statusPublished - Mar 2011


  • Convective therapies
  • Dialysis adequacy
  • Mortality
  • On-line hemodiafiltration
  • adult
  • aged
  • article
  • controlled study
  • female
  • hemodiafiltration
  • hemodialysis
  • human
  • kidney failure
  • kidney transplantation
  • major clinical study
  • male
  • mortality
  • multicenter study
  • online system
  • open study
  • prospective study
  • randomized controlled trial
  • risk reduction
  • sample size
  • Spain
  • study design
  • survival time


Dive into the research topics of 'Design and patient characteristics of ESHOL study, a Catalonian prospective randomized study'. Together they form a unique fingerprint.

Cite this