Association of d-penicillamine treated rheumatoid arthritis and dermatopolymyositis development is an event infrequently reported in the literature. The patient reported is a 50-years-old woman, with seropositive rheumatoid arthritis (latex +++; Waaler-Rose, +1/512), and positive antinuclear antibodies (1/200), for three years. Seven months after starting penicillamine therapy, she experienced weakness and pain in musculature of the limbs, associated with a facial rash suggesting dermatomyositis. Histopathologic studies confirmed the presence of skin and muscular lesions consistent with dermatomyositis, the EMG pattern was also indicative of myositis whereas enzymatic study remained normal. The clinical features of dermatomyositis disappeared after discontinuing d-penicillamine therapy, while rheumatoid arthritis has continued. Such a rapid resolution of the disease, after withdrawing d-penicillamine, suggests a drug-induced dermatomyositis.
|Journal||Revista Espanola de Reumatologia|
|Publication status||Published - 1 Jan 1980|