Dermatophagoides farinae-specific immunotherapy in atopic dogs with hypersensitivity to multiple allergens: A randomised, double blind, placebo-controlled study

T. Willemse; M. Bardagi; D. N. Carlotti; L. Ferrer; A. Fondati; J. Fontaine; M. Leistra; C. Noli; L. Ordeix; F. Scarampella; S. Schleifer; J. Sinke; P. Roosje

doi:10.1016/j.tvjl.2008.01.004

Dermatophagoides farinae-specific immunotherapy in atopic dogs with hypersensitivity to multiple allergens: A randomised, double blind, placebo-controlled study

T. Willemse, M. Bardagi, D. N. Carlotti, L. Ferrer, A. Fondati, J. Fontaine, M. Leistra, C. Noli, L. Ordeix, F. Scarampella, S. Schleifer, J. Sinke, P. Roosje

Department of Animal Medicine and Surgery

Research output: Contribution to journal › Article › Research › peer-review

19 Citations (Scopus)

Abstract

A randomised, placebo-controlled, double blind study was conducted on 25 dogs that had atopic dermatitis, together with skin test reactivity and elevated serum IgE to Dermatophagoides farinae (Df) and at least one additional allergen. Dogs were treated with either a Df-restricted immunotherapy solution (n = 14) or a placebo (n = 11) and evaluated 6 weeks and 3, 5, 7 and 9 months after the initiation of treatment using a clinical scoring system (SASSAD) and pruritus analogue scale scores. The Df-restricted solution and the placebo had an equal effect on both pruritus and the skin manifestations (P > 0.05). The results of this study indicate that in dogs with atopic dermatitis based on hypersensitivity to environmental allergens in addition to D. farinae, Df-restricted immunotherapy is insufficient to control the disease. Consequently, a solution for allergen-specific immunotherapy should remain customised. © 2008 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	337-342
Journal	Veterinary Journal
Volume	180
Issue number	3
DOIs	https://doi.org/10.1016/j.tvjl.2008.01.004
Publication status	Published - 1 Jun 2009

Keywords

Allergen-specific immunotherapy
Atopic dermatitis
Canine
Dermatophagoides farinae

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10.1016/j.tvjl.2008.01.004

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Willemse, T., Bardagi, M., Carlotti, D. N., Ferrer, L., Fondati, A., Fontaine, J., Leistra, M., Noli, C., Ordeix, L., Scarampella, F., Schleifer, S., Sinke, J., & Roosje, P. (2009). Dermatophagoides farinae-specific immunotherapy in atopic dogs with hypersensitivity to multiple allergens: A randomised, double blind, placebo-controlled study. Veterinary Journal, 180(3), 337-342. https://doi.org/10.1016/j.tvjl.2008.01.004

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title = "Dermatophagoides farinae-specific immunotherapy in atopic dogs with hypersensitivity to multiple allergens: A randomised, double blind, placebo-controlled study",

abstract = "A randomised, placebo-controlled, double blind study was conducted on 25 dogs that had atopic dermatitis, together with skin test reactivity and elevated serum IgE to Dermatophagoides farinae (Df) and at least one additional allergen. Dogs were treated with either a Df-restricted immunotherapy solution (n = 14) or a placebo (n = 11) and evaluated 6 weeks and 3, 5, 7 and 9 months after the initiation of treatment using a clinical scoring system (SASSAD) and pruritus analogue scale scores. The Df-restricted solution and the placebo had an equal effect on both pruritus and the skin manifestations (P > 0.05). The results of this study indicate that in dogs with atopic dermatitis based on hypersensitivity to environmental allergens in addition to D. farinae, Df-restricted immunotherapy is insufficient to control the disease. Consequently, a solution for allergen-specific immunotherapy should remain customised. {\textcopyright} 2008 Elsevier Ltd. All rights reserved.",

keywords = "Allergen-specific immunotherapy, Atopic dermatitis, Canine, Dermatophagoides farinae",

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Willemse, T, Bardagi, M, Carlotti, DN, Ferrer, L, Fondati, A, Fontaine, J, Leistra, M, Noli, C, Ordeix, L, Scarampella, F, Schleifer, S, Sinke, J & Roosje, P 2009, 'Dermatophagoides farinae-specific immunotherapy in atopic dogs with hypersensitivity to multiple allergens: A randomised, double blind, placebo-controlled study', Veterinary Journal, vol. 180, no. 3, pp. 337-342. https://doi.org/10.1016/j.tvjl.2008.01.004

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AU - Willemse, T.

AU - Bardagi, M.

AU - Carlotti, D. N.

AU - Ferrer, L.

AU - Fondati, A.

AU - Fontaine, J.

AU - Leistra, M.

AU - Noli, C.

AU - Ordeix, L.

AU - Scarampella, F.

AU - Schleifer, S.

AU - Sinke, J.

AU - Roosje, P.

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N2 - A randomised, placebo-controlled, double blind study was conducted on 25 dogs that had atopic dermatitis, together with skin test reactivity and elevated serum IgE to Dermatophagoides farinae (Df) and at least one additional allergen. Dogs were treated with either a Df-restricted immunotherapy solution (n = 14) or a placebo (n = 11) and evaluated 6 weeks and 3, 5, 7 and 9 months after the initiation of treatment using a clinical scoring system (SASSAD) and pruritus analogue scale scores. The Df-restricted solution and the placebo had an equal effect on both pruritus and the skin manifestations (P > 0.05). The results of this study indicate that in dogs with atopic dermatitis based on hypersensitivity to environmental allergens in addition to D. farinae, Df-restricted immunotherapy is insufficient to control the disease. Consequently, a solution for allergen-specific immunotherapy should remain customised. © 2008 Elsevier Ltd. All rights reserved.

AB - A randomised, placebo-controlled, double blind study was conducted on 25 dogs that had atopic dermatitis, together with skin test reactivity and elevated serum IgE to Dermatophagoides farinae (Df) and at least one additional allergen. Dogs were treated with either a Df-restricted immunotherapy solution (n = 14) or a placebo (n = 11) and evaluated 6 weeks and 3, 5, 7 and 9 months after the initiation of treatment using a clinical scoring system (SASSAD) and pruritus analogue scale scores. The Df-restricted solution and the placebo had an equal effect on both pruritus and the skin manifestations (P > 0.05). The results of this study indicate that in dogs with atopic dermatitis based on hypersensitivity to environmental allergens in addition to D. farinae, Df-restricted immunotherapy is insufficient to control the disease. Consequently, a solution for allergen-specific immunotherapy should remain customised. © 2008 Elsevier Ltd. All rights reserved.

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KW - Canine

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M3 - Article

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SP - 337

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ER -

Dermatophagoides farinae-specific immunotherapy in atopic dogs with hypersensitivity to multiple allergens: A randomised, double blind, placebo-controlled study

Abstract

Keywords

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