Objective: To evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis. Methods: Expression of CD69, TNF-R1, Fas, FasL, bcl-2, and bax was investigated in 41 MS patients and 12 healthy controls by flow cytometry in CD4+ and CD8+ T cells expressing CCR5 and CXCR3. Results: In MS patients, the percentage of CD69 was increased and Fas expression decreased in CD4+ CCR5+ T cells. Interpretation: The lower Fas expression in activated CD4+ CCR5+ T cells might contribute to disease pathogenesis by prolonging cell survival and favoring their migration into the CNS. © 2006 Elsevier B.V. All rights reserved.
- Multiple sclerosis
- T cells
Julià, E., Montalban, X., Al-zayat, H., Issazadeh-Navikas, S., Goertsches, R., Martin, R., & Comabella, M. (2006). Deficient Fas expression by CD4+ CCR5+ T cells in multiple sclerosis. Journal of Neuroimmunology, 180(1-2), 147-158. https://doi.org/10.1016/j.jneuroim.2006.07.001