Deficient Fas expression by CD4+ CCR5+ T cells in multiple sclerosis

Eva Julià, Xavier Montalban, Hammad Al-zayat, Shohreh Issazadeh-Navikas, Robert Goertsches, Roland Martin, Manuel Comabella

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Abstract

Objective: To evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis. Methods: Expression of CD69, TNF-R1, Fas, FasL, bcl-2, and bax was investigated in 41 MS patients and 12 healthy controls by flow cytometry in CD4+ and CD8+ T cells expressing CCR5 and CXCR3. Results: In MS patients, the percentage of CD69 was increased and Fas expression decreased in CD4+ CCR5+ T cells. Interpretation: The lower Fas expression in activated CD4+ CCR5+ T cells might contribute to disease pathogenesis by prolonging cell survival and favoring their migration into the CNS. © 2006 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)147-158
JournalJournal of Neuroimmunology
Volume180
Issue number1-2
DOIs
Publication statusPublished - 1 Nov 2006

Keywords

  • Apoptosis
  • Multiple sclerosis
  • T cells

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