Decreased sensitivity to the cytogenetic effects of bleomycin in individuals occupationally exposed to ionizing radiation

Joan Francesc Barquinero, Leonardo Barrios, Maria Rosa Caballín, Rosa Miró, Montserrat Ribas, Antoni Subias, José Egozcue

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Abstract

In the present work, 12 individuals occupationally exposed to ionizing radiation and 11 unexposed ones were studied to determine the cytogenetic effect of a challenge dose of bleomycin on their phytohemagglutinin stimulated lymphocytes. After bleomycin treatment, the frequencies of chromatid breaks and gaps were significantly lower in the exposed population (p < 0.025 for both types of chromatid alterations). These results could indicate that occupational exposure to ionizing radiation can induce an adaptive response that can be detected by a subsequent treatment with bleomycin.
Original languageEnglish
Pages (from-to)81-86
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume354
DOIs
Publication statusPublished - 5 Jul 1996

Keywords

  • Adaptive response
  • Bleomycin
  • Ionizing radiation
  • Occupational exposure

Fingerprint Dive into the research topics of 'Decreased sensitivity to the cytogenetic effects of bleomycin in individuals occupationally exposed to ionizing radiation'. Together they form a unique fingerprint.

Cite this