Decreased CX3CL1 levels in the cerebrospinal fluid of patients with Alzheimer's disease

Juan R. Perea; Alberto Lleó; Daniel Alcolea; Juan Fortea; Jesús Ávila; Marta Bolós

doi:10.3389/fnins.2018.00609

Decreased CX3CL1 levels in the cerebrospinal fluid of patients with Alzheimer's disease

Juan R. Perea, Alberto Lleó, Daniel Alcolea, Juan Fortea, Jesús Ávila, Marta Bolós

Department of Medicine

Research output: Contribution to journal › Article › Research

35 Citations (Scopus)

Abstract

© 2018 Perea, Lleó, Alcolea, Fortea, ávila and Bolós. Alzheimer's disease (AD) is a neurodegenerative disease characterized by the presence of neurofibrillary tangles, constituted by tau protein, and plaques formed by amyloid-beta protein. The disease courses with high neural damage, which leads to memory loss and death. Here we analyzed the presence of CX3CL1, a chemokine expressed by neurons, in cerebrospinal fluid (CSF) samples from control subjects and patients with mild cognitive impairment and AD dementia. CX3CL1 was decreased in the CSF of AD dementia patients compared to control subjects. However, there was not difference in plasma samples from the same subjects.

Original language	English
Article number	609
Journal	Frontiers in Neuroscience
Volume	12
DOIs	https://doi.org/10.3389/fnins.2018.00609
Publication status	Published - 7 Sept 2018

Keywords

Alzheimer's disease
CX3CL1
Human CSF
Inflammation
Microglia
Tau

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fnins.2018.00609

https://ddd.uab.cat/record/253654

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title = "Decreased CX3CL1 levels in the cerebrospinal fluid of patients with Alzheimer's disease",

abstract = "{\textcopyright} 2018 Perea, Lle{\'o}, Alcolea, Fortea, {\'a}vila and Bol{\'o}s. Alzheimer's disease (AD) is a neurodegenerative disease characterized by the presence of neurofibrillary tangles, constituted by tau protein, and plaques formed by amyloid-beta protein. The disease courses with high neural damage, which leads to memory loss and death. Here we analyzed the presence of CX3CL1, a chemokine expressed by neurons, in cerebrospinal fluid (CSF) samples from control subjects and patients with mild cognitive impairment and AD dementia. CX3CL1 was decreased in the CSF of AD dementia patients compared to control subjects. However, there was not difference in plasma samples from the same subjects.",

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AU - Perea, Juan R.

AU - Lleó, Alberto

AU - Alcolea, Daniel

AU - Fortea, Juan

AU - Ávila, Jesús

AU - Bolós, Marta

PY - 2018/9/7

Y1 - 2018/9/7

N2 - © 2018 Perea, Lleó, Alcolea, Fortea, ávila and Bolós. Alzheimer's disease (AD) is a neurodegenerative disease characterized by the presence of neurofibrillary tangles, constituted by tau protein, and plaques formed by amyloid-beta protein. The disease courses with high neural damage, which leads to memory loss and death. Here we analyzed the presence of CX3CL1, a chemokine expressed by neurons, in cerebrospinal fluid (CSF) samples from control subjects and patients with mild cognitive impairment and AD dementia. CX3CL1 was decreased in the CSF of AD dementia patients compared to control subjects. However, there was not difference in plasma samples from the same subjects.

AB - © 2018 Perea, Lleó, Alcolea, Fortea, ávila and Bolós. Alzheimer's disease (AD) is a neurodegenerative disease characterized by the presence of neurofibrillary tangles, constituted by tau protein, and plaques formed by amyloid-beta protein. The disease courses with high neural damage, which leads to memory loss and death. Here we analyzed the presence of CX3CL1, a chemokine expressed by neurons, in cerebrospinal fluid (CSF) samples from control subjects and patients with mild cognitive impairment and AD dementia. CX3CL1 was decreased in the CSF of AD dementia patients compared to control subjects. However, there was not difference in plasma samples from the same subjects.

KW - Alzheimer's disease

KW - CX3CL1

KW - Human CSF

KW - Inflammation

KW - Microglia

KW - Tau

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DO - 10.3389/fnins.2018.00609

M3 - Article

C2 - 30245615

VL - 12

M1 - 609

ER -

Decreased CX3CL1 levels in the cerebrospinal fluid of patients with Alzheimer's disease

Abstract

Keywords

UN SDGs

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