Projects per year
Prions are self-propagating proteins that cause fatal neurodegenerative diseases in humans. However, increasing evidence suggests that eukaryotic cells exploit prion conformational conversion for functional purposes. A recent study delineated a group of twenty prion-like proteins in humans, characterized by the presence of low-complexity glutamine-rich sequences with overlapping coiled-coil (CCs) motifs. This is the case of Mediator complex subunit 15 (MED15), which is overexpressed in a wide range of human cancers. Biophysical studies demonstrated that the prion-like domain (PrLD) of MED15 forms homodimers in solution, sustained by CCs interactions. Furthermore, the same coiled-coil (CC) region plays a crucial role in the PrLD structural transition to a transmissible β-sheet amyloid state. In this review, we discuss the role of CCs motifs and their contribution to amyloid transitions in human prion-like domains (PrLDs), while providing a comprehensive overview of six predicted human prion-like proteins involved in transcription, gene expression, or DNA damage response and associated with human disease, whose PrLDs contain or overlap with CCs sequences. Finally, we try to rationalize how these molecular signatures might relate to both their function and involvement in disease.
|Number of pages||12|
|Publication status||Published - 24 Aug 2021|
- prion-like domains
- protein aggregation
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- 1 Active
PROTEIN AGGREGATION: BIOMEDICAL AND BIOTECHNOLOGICAL APPLICATIONS
Ventura Zamora, S., Batlle Carreras, C., Baño Polo, M., Diaz Caballero, M., Garcia de Carvalho Pinheiro, F., Iglesias Mas, J. V., Navarro Cantero, S., Peña Diaz, S., Pujols Pujol, J., Fernandez Gallegos, M. R., Pallares Goitiz, I., Gil-Garcia, M., SANTOS SUAREZ, J., Wang, W. & Garcia Pardo, J.
1/06/20 → 31/05/23
Project: Research Projects and Other Grants