Dealing with uncertainty in the treatment of Helicobacter pylori

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© 2018, © The Author(s), 2018. Helicobacter pylori treatment may be viewed as an uncertain situation, where current knowledge is insufficient to provide evidence-based recommendations for all possible scenarios. Evidence suggests that, under uncertainty conditions, a few simple rules of thumb tend to work better than complex algorithms. Overall, five evidence-based rules of thumb are suggested: (1) Use four drugs; (2) Use maximal acid inhibition; (3) Treat for 2 weeks; (4) Do not repeat antibiotics after treatment failure; and (5) If your treatment works locally, keep using it. These simple rules of thumb may help the reader to select the best alternative for a given patient, choosing between the heterogeneous recommendations provided by the many different consensus conferences on H. pylori treatment recently published.
Original languageEnglish
Pages (from-to)93-102
JournalTherapeutic Advances in Chronic Disease
Issue number4
Publication statusPublished - 1 Apr 2018


  • Helicobacter pylori
  • treatment
  • uncertainty


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