Darwinian medicine and psoriasis

J. Romaní de Gabriel

Research output: Contribution to journalReview articleResearchpeer-review

1 Citation (Scopus)


Copyright © 2014 Elsevier España, S.L.U. and AEDV. All rights reserved. Darwinian medicine, or evolutionary medicine, regards some pathological conditions as attempts by the organism to solve a problem or develop defense mechanisms. At certain stages of human evolution, some diseases may have conferred a selective advantage. Psoriasis is a high-penetrance multigenic disorder with prevalence among whites of up to 3%. Psoriatic lesions have been linked with enhanced wound-healing qualities and greater capacity to fight infection. Leprosy, tuberculosis, and infections caused by viruses similar to human immunodeficiency virus have been postulated as environmental stressors that may have selected for psoriasis-promoting genes in some human populations. The tendency of patients with severe psoriasis to develop metabolic syndrome may reflect the body's attempt to react to environmental stresses and warning signs by triggering insulin resistance and fat storage.
Original languageEnglish
Pages (from-to)189-194
JournalActas dermo-sifiliograficas
Issue number3
Publication statusPublished - 1 Apr 2015


  • Chemical shield
  • Darwinian medicine
  • Escudo químico
  • Evolutionary medicine
  • Medicina darwiniana
  • Medicina evolutiva
  • Metabolic syndrome
  • Psoriasis
  • Síndrome metabólico


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