D-Cycloserine in prelimbic cortex enhances relearning of an odor-reward associative task

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Abstract

We investigated the effects of bilateral infusions in the prelimbic cortex of d-cycloserine (DCS), a partial agonist of the NMDA receptor-associated glycine site. Wistar rats underwent a training session (acquisition, three trials) and a 24-h test (two retention and two relearning trials) of a rapidly learned olfactory discrimination task. Rats infused with DCS (10 μg/site) prior to training exhibited a significant enhancement of performance in such odor-reward task, especially in relearning. © 2010 Elsevier B.V.
Original languageEnglish
Pages (from-to)113-116
JournalBehavioural Brain Research
Volume213
Issue number1
DOIs
Publication statusPublished - 1 Jan 2010

Keywords

  • Glutamate
  • Glycine-modulatory site
  • Medial prefrontal cortex
  • NMDA receptors
  • Odor discrimination learning
  • Prelimbic cortex
  • Relearning

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