Cytokine profiles and phenotype regulation of antigen presenting cells by genotype-I porcine reproductive and respiratory syndrome virus isolates

Mariona Gimeno, Laila Darwich, Ivan Diaz, Eugenia De La Torre, Joan Pujols, Marga Martín, Shigeki Inumaru, Esmeralda Cano, Mariano Domingo, Maria Montoya, Enric Mateu

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Abstract

The present study examined the immunological response of antigen presenting cells (APC) to genotype-I isolates of porcine reproductive and respiratory syndrome virus (PRRSV) infection by analysing the cytokine profile induced and evaluating the changes taking place upon infection on immunologically relevant cell markers (MHCI, MHCII, CD80/86, CD14, CD16, CD163, CD172a, SWC9). Several types of APC were infected with 39 PRRSV isolates. The results show that different isolates were able to induce different patterns of IL-10 and TNF-. The four possible phenotypes based on the ability to induce IL-10 and/or TNF- were observed, although different cell types seemed to have different capabilities. In addition, isolates inducing different cytokine-release profiles on APC could induce different expression of cell markers. © 2011 Gimeno et al; licensee BioMed Central Ltd.
Original languageEnglish
Article number9
JournalVeterinary Research
Volume42
DOIs
Publication statusPublished - 29 Aug 2011

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