Cytokine profiles and phenotype regulation of antigen presenting cells by genotype-I porcine reproductive and respiratory syndrome virus isolates

Mariona Gimeno; Laila Darwich; Ivan Diaz; Eugenia De La Torre; Joan Pujols; Marga Martín; Shigeki Inumaru; Esmeralda Cano; Mariano Domingo; Maria Montoya; Enric Mateu

doi:10.1186/1297-9716-42-9

Cytokine profiles and phenotype regulation of antigen presenting cells by genotype-I porcine reproductive and respiratory syndrome virus isolates

Mariona Gimeno, Laila Darwich, Ivan Diaz, Eugenia De La Torre, Joan Pujols, Marga Martín, Shigeki Inumaru, Esmeralda Cano, Mariano Domingo, Maria Montoya, Enric Mateu

Department of Animal Health and Anatomy

Research output: Contribution to journal › Article › Research › peer-review

81 Citations (Scopus)

Abstract

The present study examined the immunological response of antigen presenting cells (APC) to genotype-I isolates of porcine reproductive and respiratory syndrome virus (PRRSV) infection by analysing the cytokine profile induced and evaluating the changes taking place upon infection on immunologically relevant cell markers (MHCI, MHCII, CD80/86, CD14, CD16, CD163, CD172a, SWC9). Several types of APC were infected with 39 PRRSV isolates. The results show that different isolates were able to induce different patterns of IL-10 and TNF-. The four possible phenotypes based on the ability to induce IL-10 and/or TNF- were observed, although different cell types seemed to have different capabilities. In addition, isolates inducing different cytokine-release profiles on APC could induce different expression of cell markers. © 2011 Gimeno et al; licensee BioMed Central Ltd.

Original language	English
Article number	9
Journal	Veterinary Research
Volume	42
DOIs	https://doi.org/10.1186/1297-9716-42-9
Publication status	Published - 29 Aug 2011

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title = "Cytokine profiles and phenotype regulation of antigen presenting cells by genotype-I porcine reproductive and respiratory syndrome virus isolates",

abstract = "The present study examined the immunological response of antigen presenting cells (APC) to genotype-I isolates of porcine reproductive and respiratory syndrome virus (PRRSV) infection by analysing the cytokine profile induced and evaluating the changes taking place upon infection on immunologically relevant cell markers (MHCI, MHCII, CD80/86, CD14, CD16, CD163, CD172a, SWC9). Several types of APC were infected with 39 PRRSV isolates. The results show that different isolates were able to induce different patterns of IL-10 and TNF-. The four possible phenotypes based on the ability to induce IL-10 and/or TNF- were observed, although different cell types seemed to have different capabilities. In addition, isolates inducing different cytokine-release profiles on APC could induce different expression of cell markers. {\textcopyright} 2011 Gimeno et al; licensee BioMed Central Ltd.",

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TY - JOUR

T1 - Cytokine profiles and phenotype regulation of antigen presenting cells by genotype-I porcine reproductive and respiratory syndrome virus isolates

AU - Gimeno, Mariona

AU - Darwich, Laila

AU - Diaz, Ivan

AU - De La Torre, Eugenia

AU - Pujols, Joan

AU - Martín, Marga

AU - Inumaru, Shigeki

AU - Cano, Esmeralda

AU - Domingo, Mariano

AU - Montoya, Maria

AU - Mateu, Enric

PY - 2011/8/29

Y1 - 2011/8/29

N2 - The present study examined the immunological response of antigen presenting cells (APC) to genotype-I isolates of porcine reproductive and respiratory syndrome virus (PRRSV) infection by analysing the cytokine profile induced and evaluating the changes taking place upon infection on immunologically relevant cell markers (MHCI, MHCII, CD80/86, CD14, CD16, CD163, CD172a, SWC9). Several types of APC were infected with 39 PRRSV isolates. The results show that different isolates were able to induce different patterns of IL-10 and TNF-. The four possible phenotypes based on the ability to induce IL-10 and/or TNF- were observed, although different cell types seemed to have different capabilities. In addition, isolates inducing different cytokine-release profiles on APC could induce different expression of cell markers. © 2011 Gimeno et al; licensee BioMed Central Ltd.

AB - The present study examined the immunological response of antigen presenting cells (APC) to genotype-I isolates of porcine reproductive and respiratory syndrome virus (PRRSV) infection by analysing the cytokine profile induced and evaluating the changes taking place upon infection on immunologically relevant cell markers (MHCI, MHCII, CD80/86, CD14, CD16, CD163, CD172a, SWC9). Several types of APC were infected with 39 PRRSV isolates. The results show that different isolates were able to induce different patterns of IL-10 and TNF-. The four possible phenotypes based on the ability to induce IL-10 and/or TNF- were observed, although different cell types seemed to have different capabilities. In addition, isolates inducing different cytokine-release profiles on APC could induce different expression of cell markers. © 2011 Gimeno et al; licensee BioMed Central Ltd.

U2 - 10.1186/1297-9716-42-9

DO - 10.1186/1297-9716-42-9

M3 - Article

SN - 0928-4249

VL - 42

JO - Veterinary Research

JF - Veterinary Research

M1 - 9

ER -

Cytokine profiles and phenotype regulation of antigen presenting cells by genotype-I porcine reproductive and respiratory syndrome virus isolates

Abstract

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