Cytogenetic sensitivity of three Fanconi anemia heterozygotes to bleomycin and ionizing radiation

Joan Francesc Barquinero, Leonardo Barrios, Montserrat Ribas, Josep Egozcue, María Rosa Caballín

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15 Citations (Scopus)

Abstract

It is well known that Fanconi anemia (FA) patients show a hypersensitivity to the effect of cross-linking agents such as mitomycin C and diepoxybutane, while the sensitivity of these patients to ionizing radiation is controversial. Fanconi anemia heterozygotes do not show a hypersensitivity to the above-mentioned agents. However, bleomycin it is used to identify mutagen sensitive individuals, especially among head and neck cancer patients. We present here a preliminary study in which the mean frequencies of bleomycin-induced chromatid breaks (ctb) from three FA heterozygotes (X = 0.90, range 0.80-1.01) and 11 controls (X = 0.40, range 0.21-0.66) differ significantly (P<.001), indicating a high sensitivity to bleomycin of G2 lymphocytes from these three FA heterozygotes. An increased sensitivity was not observed after exposure of G0 lymphocytes to 2 Gy of ionizing radiation. Copyright © 2000 Elsevier Science Inc.
Original languageEnglish
Pages (from-to)80-83
JournalCancer Genetics and Cytogenetics
Volume124
DOIs
Publication statusPublished - 1 Jan 2001

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