Cytogenetic sensitivity of three Fanconi anemia heterozygotes to bleomycin and ionizing radiation

Joan Francesc Barquinero; Leonardo Barrios; Montserrat Ribas; Josep Egozcue; María Rosa Caballín

doi:https://doi.org/10.1016/S0165-4608(00)00326-5

Cytogenetic sensitivity of three Fanconi anemia heterozygotes to bleomycin and ionizing radiation

Joan Francesc Barquinero, Leonardo Barrios, Montserrat Ribas, Josep Egozcue, María Rosa Caballín

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

It is well known that Fanconi anemia (FA) patients show a hypersensitivity to the effect of cross-linking agents such as mitomycin C and diepoxybutane, while the sensitivity of these patients to ionizing radiation is controversial. Fanconi anemia heterozygotes do not show a hypersensitivity to the above-mentioned agents. However, bleomycin it is used to identify mutagen sensitive individuals, especially among head and neck cancer patients. We present here a preliminary study in which the mean frequencies of bleomycin-induced chromatid breaks (ctb) from three FA heterozygotes (X = 0.90, range 0.80-1.01) and 11 controls (X = 0.40, range 0.21-0.66) differ significantly (P<.001), indicating a high sensitivity to bleomycin of G2 lymphocytes from these three FA heterozygotes. An increased sensitivity was not observed after exposure of G0 lymphocytes to 2 Gy of ionizing radiation. Copyright © 2000 Elsevier Science Inc.

Original language	English
Pages (from-to)	80-83
Journal	Cancer Genetics and Cytogenetics
Volume	124
DOIs	https://doi.org/10.1016/S0165-4608(00)00326-5
Publication status	Published - 1 Jan 2001

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title = "Cytogenetic sensitivity of three Fanconi anemia heterozygotes to bleomycin and ionizing radiation",

abstract = "It is well known that Fanconi anemia (FA) patients show a hypersensitivity to the effect of cross-linking agents such as mitomycin C and diepoxybutane, while the sensitivity of these patients to ionizing radiation is controversial. Fanconi anemia heterozygotes do not show a hypersensitivity to the above-mentioned agents. However, bleomycin it is used to identify mutagen sensitive individuals, especially among head and neck cancer patients. We present here a preliminary study in which the mean frequencies of bleomycin-induced chromatid breaks (ctb) from three FA heterozygotes (X = 0.90, range 0.80-1.01) and 11 controls (X = 0.40, range 0.21-0.66) differ significantly (P<.001), indicating a high sensitivity to bleomycin of G2 lymphocytes from these three FA heterozygotes. An increased sensitivity was not observed after exposure of G0 lymphocytes to 2 Gy of ionizing radiation. Copyright {\textcopyright} 2000 Elsevier Science Inc.",

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T1 - Cytogenetic sensitivity of three Fanconi anemia heterozygotes to bleomycin and ionizing radiation

AU - Barquinero, Joan Francesc

AU - Barrios, Leonardo

AU - Ribas, Montserrat

AU - Egozcue, Josep

AU - Caballín, María Rosa

PY - 2001/1/1

Y1 - 2001/1/1

N2 - It is well known that Fanconi anemia (FA) patients show a hypersensitivity to the effect of cross-linking agents such as mitomycin C and diepoxybutane, while the sensitivity of these patients to ionizing radiation is controversial. Fanconi anemia heterozygotes do not show a hypersensitivity to the above-mentioned agents. However, bleomycin it is used to identify mutagen sensitive individuals, especially among head and neck cancer patients. We present here a preliminary study in which the mean frequencies of bleomycin-induced chromatid breaks (ctb) from three FA heterozygotes (X = 0.90, range 0.80-1.01) and 11 controls (X = 0.40, range 0.21-0.66) differ significantly (P<.001), indicating a high sensitivity to bleomycin of G2 lymphocytes from these three FA heterozygotes. An increased sensitivity was not observed after exposure of G0 lymphocytes to 2 Gy of ionizing radiation. Copyright © 2000 Elsevier Science Inc.

AB - It is well known that Fanconi anemia (FA) patients show a hypersensitivity to the effect of cross-linking agents such as mitomycin C and diepoxybutane, while the sensitivity of these patients to ionizing radiation is controversial. Fanconi anemia heterozygotes do not show a hypersensitivity to the above-mentioned agents. However, bleomycin it is used to identify mutagen sensitive individuals, especially among head and neck cancer patients. We present here a preliminary study in which the mean frequencies of bleomycin-induced chromatid breaks (ctb) from three FA heterozygotes (X = 0.90, range 0.80-1.01) and 11 controls (X = 0.40, range 0.21-0.66) differ significantly (P<.001), indicating a high sensitivity to bleomycin of G2 lymphocytes from these three FA heterozygotes. An increased sensitivity was not observed after exposure of G0 lymphocytes to 2 Gy of ionizing radiation. Copyright © 2000 Elsevier Science Inc.

U2 - https://doi.org/10.1016/S0165-4608(00)00326-5

DO - https://doi.org/10.1016/S0165-4608(00)00326-5

M3 - Article

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SP - 80

EP - 83

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Cytogenetic sensitivity of three Fanconi anemia heterozygotes to bleomycin and ionizing radiation

Abstract

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