TY - JOUR
T1 - Cytogenetic sensitivity of three Fanconi anemia heterozygotes to bleomycin and ionizing radiation
AU - Barquinero, Joan Francesc
AU - Barrios, Leonardo
AU - Ribas, Montserrat
AU - Egozcue, Josep
AU - Caballín, María Rosa
PY - 2001/1/1
Y1 - 2001/1/1
N2 - It is well known that Fanconi anemia (FA) patients show a hypersensitivity to the effect of cross-linking agents such as mitomycin C and diepoxybutane, while the sensitivity of these patients to ionizing radiation is controversial. Fanconi anemia heterozygotes do not show a hypersensitivity to the above-mentioned agents. However, bleomycin it is used to identify mutagen sensitive individuals, especially among head and neck cancer patients. We present here a preliminary study in which the mean frequencies of bleomycin-induced chromatid breaks (ctb) from three FA heterozygotes (X = 0.90, range 0.80-1.01) and 11 controls (X = 0.40, range 0.21-0.66) differ significantly (P<.001), indicating a high sensitivity to bleomycin of G2 lymphocytes from these three FA heterozygotes. An increased sensitivity was not observed after exposure of G0 lymphocytes to 2 Gy of ionizing radiation. Copyright © 2000 Elsevier Science Inc.
AB - It is well known that Fanconi anemia (FA) patients show a hypersensitivity to the effect of cross-linking agents such as mitomycin C and diepoxybutane, while the sensitivity of these patients to ionizing radiation is controversial. Fanconi anemia heterozygotes do not show a hypersensitivity to the above-mentioned agents. However, bleomycin it is used to identify mutagen sensitive individuals, especially among head and neck cancer patients. We present here a preliminary study in which the mean frequencies of bleomycin-induced chromatid breaks (ctb) from three FA heterozygotes (X = 0.90, range 0.80-1.01) and 11 controls (X = 0.40, range 0.21-0.66) differ significantly (P<.001), indicating a high sensitivity to bleomycin of G2 lymphocytes from these three FA heterozygotes. An increased sensitivity was not observed after exposure of G0 lymphocytes to 2 Gy of ionizing radiation. Copyright © 2000 Elsevier Science Inc.
U2 - https://doi.org/10.1016/S0165-4608(00)00326-5
DO - https://doi.org/10.1016/S0165-4608(00)00326-5
M3 - Article
VL - 124
SP - 80
EP - 83
ER -