Cytogenetic effects of radiotherapy: Frequency and types of chromosome aberrations

Leonardo Barrios, Maria Rosa Caballín, Rosa Miró, Carme Fuster, Ferràn Guedea, Antoni Subias, Josep Egozcue

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

The frequency and types of chromosome aberrations induced by ionizing radiation in cancer patients were evaluated in 24 cases studied just before and immediately after radiotherapy. The incidence of aberrant metaphases prior to treatment was 9.913% and increased significantly after treatment to 32.8%. The frequency of chromosome aberrations before radiotherapy was, with the exception of the cases of breast cancer and seminoma, significantly higher than that in our laboratory controls. A comparison of chromosome abnormalities observed before and after treatment indicated that dicentric translocations, rings, and reciprocal translocations increased by a factor of 23, 13, and 11, respectively, after radiotherapy. Ionizing radiation produces more asymmetrical than symmetrical chromosome aberrations and more two-break than one-break anomalies. © 1990.
Original languageEnglish
Pages (from-to)371-375
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume19
DOIs
Publication statusPublished - 1 Jan 1990

Keywords

  • Chromosome aberrations
  • Radiotherapy

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