Cytogenetic complexity in chronic lymphocytic leukemia: Definitions, associations, and clinical impact

Panagiotis Baliakas, Sabine Jeromin, Michalis Iskas, Anna Puiggros, Karla Plevova, Florence Nguyen-Khac, Zadie Davis, Gian Matteo Rigolin, Andrea Visentin, Aliki Xochelli, Julio Delgado, Fanny Baran-Marszak, Evangelia Stalika, Pau Abrisqueta, Kristina Durechova, George Papaioannou, Virginie Eclache, Maria DImou, Theodoros Iliakis, Rosa ColladoMichael Doubek, M. Jose Calasanz, Neus Ruiz-Xiville, Carolina Moreno, Marie Jarosova, Alexander C. Leeksma, Panayiotis Panayiotidis, Helena Podgornik, Florence Cymbalista, Achilles Anagnostopoulos, Livio Trentin, Niki Stavroyianni, Fred Davi, Paolo Ghia, Arnon P. Kater, Antonio Cuneo, Sarka Pospisilova, Blanca Espinet, Anastasia Athanasiadou, David Oscier, Claudia Haferlach, Kostas Stamatopoulos

    Research output: Contribution to journalArticleResearch

    33 Citations (Scopus)

    Abstract

    © 2019 by The American Society of Hematology. Recent evidence suggests that complex karyotype (CK) defined by the presence of ≥3 chromosomal aberrations (structural and/or numerical) identified by using chromosomebanding analysis (CBA) may be relevant for treatment decision-making in chronic lymphocytic leukemia (CLL). However, many challenges toward the routine clinical application of CBA remain. In a retrospective study of 5290 patients with available CBA data, we explored both clinicobiological associations and the clinical impact of CK in CLL. We found that patients with ≥5 abnormalities, defined as high-CK, exhibit uniformly dismal clinical outcomes, independently of clinical stage, TP53 aberrations (deletion of chromosome 17p and/or TP53 mutations [TP53abs]), and the expression of somatically hypermutated (M-CLL) or unmutated immunoglobulin heavy variable genes. Thus, they contrasted with CK cases with 3 or 4 aberrations (low-CK and intermediate-CK, respectively) who followed aggressive disease courses only in the presence of TP53abs. At the other end of the spectrum, patients with CK and +12,+19 displayed an exceptionally indolent profile. Building upon CK, TP53abs, and immunoglobulin heavy variable gene somatic hypermutation status, we propose a novel hierarchical model in which patients with high-CK exhibit the worst prognosis, whereas those with mutated CLL lacking CK or TP53abs, as well as CK with +12,+19, show the longest overall survival. Thus, CK should not be axiomatically considered unfavorable in CLL, representing a heterogeneous group with variable clinical behavior. High-CK with ≥5 chromosomal aberrations emerges as prognostically adverse, independent of other biomarkers. Prospective clinical validation is warranted before ultimately incorporating high-CK in risk stratification of CLL.
    Original languageEnglish
    Pages (from-to)1205-1216
    Number of pages12
    JournalBlood
    Volume133
    Issue number11
    DOIs
    Publication statusPublished - 14 Mar 2019

    Keywords

    • Aged
    • Biomarkers, Tumor/genetics
    • Chromosome Aberrations
    • Cytogenetics/methods
    • Female
    • Follow-Up Studies
    • Humans
    • Leukemia, Lymphocytic, Chronic, B-Cell/genetics
    • Male
    • Middle Aged
    • Mutation
    • Prognosis
    • Retrospective Studies
    • Somatic Hypermutation, Immunoglobulin/genetics
    • Survival Rate
    • Tumor Suppressor Protein p53/genetics
    • CLL PATIENTS
    • RISK GENOMIC ABERRATIONS
    • IN-SITU HYBRIDIZATION
    • CHROMOSOME-BANDING ANALYSIS
    • RECURRENT MUTATIONS
    • CONVENTIONAL CYTOGENETICS
    • CLONAL EVOLUTION
    • HEALTH-ORGANIZATION CLASSIFICATION
    • PROGNOSTIC INDEX
    • CPG OLIGONUCLEOTIDE

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