TY - JOUR
T1 - Cytogenetic aberrations and their prognostic value in a series of 330 splenic marginal zone B-cell lymphomas: A multicenter study of the Splenic B-Cell Lymphoma Group
AU - Salido, Marta
AU - Baró, Cristina
AU - Oscier, David
AU - Stamatopoulos, Kostas
AU - Dierlamm, Judith
AU - Matutes, Estela
AU - Traverse-Glehen, Alexandra
AU - Berger, Francoise
AU - Felman, Pascale
AU - Thieblemont, Catherine
AU - Gesk, Stefan
AU - Athanasiadou, Anastasia
AU - Davis, Zadie
AU - Gardiner, Anne
AU - Milla, Fuensanta
AU - Ferrer, Ana
AU - Mollejo, Manuela
AU - Calasanz, Maria José
AU - Florensa, Lourdes
AU - Espinet, Blanca
AU - Luño, Elisa
AU - Wlodarska, Iwona
AU - Verhoef, Gregor
AU - García-Granero, Marta
AU - Salar, Antonio
AU - Papadaki, Theodora
AU - Serrano, Sergio
AU - Piris, Miguel A.
AU - Solé, Francesc
PY - 2010/9/2
Y1 - 2010/9/2
N2 - We conducted a retrospective collaborative study to cytogenetically characterize splenic marginal zone lymphoma (SMZL) and ascertain the prognostic value of chromosomal aberrations. Of 330 cases, 72% displayed an aberrant karyotype, 53% were complex, and 29% had a single aberration. The predominant aberrations were gains of 3/3q and 12q, deletions of 7q and 6q and translocations involving 8q/1q/14q. CD5 expression was detected in 39 of 158 cases (25%). The cytogenetic makeup of the CD5+ group differed significantly from that of the CD5- group. Cases with unmutated IGHV were significantly associated with deletions of 7q and TP53. A strong association was noted between usage of the IGVH1-2 and deletion 7q, 14q alterations, and abnormal karyotype. On univariate analysis, patients with more than or equal to 2 aberrations, 14q alterations, and TP53 deletions had the shortest survival; 7q deletion did not affect survival. On multivariate analysis, cytogenetic aberrations did not retain prognostic significance; the parameters negatively affecting survival were hemoglobin and age. In conclusion, the cytogenetic profile of SMZL is distinct from other B-cell lymphomas. Complexity of the karyotype, 14q aberrations, and TP53 deletions are poor prognostic indicators and may be considered together with other clinicobiologic parameters to ascertain the prognosis of SMZL. © 2010 by The American Society of Hematology.
AB - We conducted a retrospective collaborative study to cytogenetically characterize splenic marginal zone lymphoma (SMZL) and ascertain the prognostic value of chromosomal aberrations. Of 330 cases, 72% displayed an aberrant karyotype, 53% were complex, and 29% had a single aberration. The predominant aberrations were gains of 3/3q and 12q, deletions of 7q and 6q and translocations involving 8q/1q/14q. CD5 expression was detected in 39 of 158 cases (25%). The cytogenetic makeup of the CD5+ group differed significantly from that of the CD5- group. Cases with unmutated IGHV were significantly associated with deletions of 7q and TP53. A strong association was noted between usage of the IGVH1-2 and deletion 7q, 14q alterations, and abnormal karyotype. On univariate analysis, patients with more than or equal to 2 aberrations, 14q alterations, and TP53 deletions had the shortest survival; 7q deletion did not affect survival. On multivariate analysis, cytogenetic aberrations did not retain prognostic significance; the parameters negatively affecting survival were hemoglobin and age. In conclusion, the cytogenetic profile of SMZL is distinct from other B-cell lymphomas. Complexity of the karyotype, 14q aberrations, and TP53 deletions are poor prognostic indicators and may be considered together with other clinicobiologic parameters to ascertain the prognosis of SMZL. © 2010 by The American Society of Hematology.
U2 - 10.1182/blood-2010-02-267476
DO - 10.1182/blood-2010-02-267476
M3 - Article
VL - 116
SP - 1479
EP - 1488
JO - Blood
JF - Blood
SN - 0006-4971
IS - 9
ER -