Cyclophosphamide-induced synaptonemal complex damage during meiotic prophase of female Rattus norvegicus

L. Cusidó; R. Pujol; J. Egozcue; M. García

doi:https://doi.org/10.1016/0027-5107(95)00029-I

Cyclophosphamide-induced synaptonemal complex damage during meiotic prophase of female Rattus norvegicus

L. Cusidó, R. Pujol, J. Egozcue, M. García

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Abstract

The reproductive system can be especially sensitive to the toxic, carcinogenic or mutagenic effects of alkylating agents. However, since studies of such effects on germ cells are complex, their analysis has been frequently overlooked. In humans, occupational or therapeutic exposure to cyclophosphamide has been associated with male (azoospermia) and female (ovarian failure) sterility or infertility. In this work, we have studied the effect of cyclophosphamide on the formation of the synaptonemal complexes in female rat fetuses. Our results indicate that cyclophosphamide administered at 16 days of gestation, when most germ cells are in a proliferative stage in the female rat, significantly increases the frequency of synaptonemal complex and nucleolar fragmentation in a dose-dependent way. © 1995.

Original language	English
Pages (from-to)	131-141
Journal	Mutation Research
Volume	329
DOIs	https://doi.org/10.1016/0027-5107(95)00029-I
Publication status	Published - 1 Jan 1995

Keywords

Cyclophosphamide
Genotoxicity
Meiosis
Synaptonemal complex

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title = "Cyclophosphamide-induced synaptonemal complex damage during meiotic prophase of female Rattus norvegicus",

abstract = "The reproductive system can be especially sensitive to the toxic, carcinogenic or mutagenic effects of alkylating agents. However, since studies of such effects on germ cells are complex, their analysis has been frequently overlooked. In humans, occupational or therapeutic exposure to cyclophosphamide has been associated with male (azoospermia) and female (ovarian failure) sterility or infertility. In this work, we have studied the effect of cyclophosphamide on the formation of the synaptonemal complexes in female rat fetuses. Our results indicate that cyclophosphamide administered at 16 days of gestation, when most germ cells are in a proliferative stage in the female rat, significantly increases the frequency of synaptonemal complex and nucleolar fragmentation in a dose-dependent way. {\textcopyright} 1995.",

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T1 - Cyclophosphamide-induced synaptonemal complex damage during meiotic prophase of female Rattus norvegicus

AU - Cusidó, L.

AU - Pujol, R.

AU - Egozcue, J.

AU - García, M.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - The reproductive system can be especially sensitive to the toxic, carcinogenic or mutagenic effects of alkylating agents. However, since studies of such effects on germ cells are complex, their analysis has been frequently overlooked. In humans, occupational or therapeutic exposure to cyclophosphamide has been associated with male (azoospermia) and female (ovarian failure) sterility or infertility. In this work, we have studied the effect of cyclophosphamide on the formation of the synaptonemal complexes in female rat fetuses. Our results indicate that cyclophosphamide administered at 16 days of gestation, when most germ cells are in a proliferative stage in the female rat, significantly increases the frequency of synaptonemal complex and nucleolar fragmentation in a dose-dependent way. © 1995.

AB - The reproductive system can be especially sensitive to the toxic, carcinogenic or mutagenic effects of alkylating agents. However, since studies of such effects on germ cells are complex, their analysis has been frequently overlooked. In humans, occupational or therapeutic exposure to cyclophosphamide has been associated with male (azoospermia) and female (ovarian failure) sterility or infertility. In this work, we have studied the effect of cyclophosphamide on the formation of the synaptonemal complexes in female rat fetuses. Our results indicate that cyclophosphamide administered at 16 days of gestation, when most germ cells are in a proliferative stage in the female rat, significantly increases the frequency of synaptonemal complex and nucleolar fragmentation in a dose-dependent way. © 1995.

KW - Cyclophosphamide

KW - Genotoxicity

KW - Meiosis

KW - Synaptonemal complex

U2 - https://doi.org/10.1016/0027-5107(95)00029-I

DO - https://doi.org/10.1016/0027-5107(95)00029-I

M3 - Article

VL - 329

SP - 131

EP - 141

ER -

Cyclophosphamide-induced synaptonemal complex damage during meiotic prophase of female Rattus norvegicus

Abstract

Keywords

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