Cyclobutyl-carbonyl substituted PNA: synthesis and study of a novel PNA derivative

Gemma P. Aguado, Federico Rúa, Vicenç Branchadell, Peter E. Nielsen, Rosa M. Ortuño

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)


A new, optically active, cyclobutyl-carbonyl substituted PNA monomer has been synthesized stereoselectively from a chiral amino acid prepared from (+)-α-pinene. A conformational search shows a lack of conformational bias for the monomer and incorporation of the monomer into a standard oligomer is tolerated without changing the binding affinity towards sequence complementary RNA, DNA or PNA targets. © 2006 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)2499-2503
JournalTetrahedron Asymmetry
Issue number17
Publication statusPublished - 2 Oct 2006


Dive into the research topics of 'Cyclobutyl-carbonyl substituted PNA: synthesis and study of a novel PNA derivative'. Together they form a unique fingerprint.

Cite this