Abstract
A new, optically active, cyclobutyl-carbonyl substituted PNA monomer has been synthesized stereoselectively from a chiral amino acid prepared from (+)-α-pinene. A conformational search shows a lack of conformational bias for the monomer and incorporation of the monomer into a standard oligomer is tolerated without changing the binding affinity towards sequence complementary RNA, DNA or PNA targets. © 2006 Elsevier Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 2499-2503 |
Journal | Tetrahedron Asymmetry |
Volume | 17 |
Issue number | 17 |
DOIs | |
Publication status | Published - 2 Oct 2006 |