Cycloadditions of highly functionalized C6-synthons to cyclic nitrones

Montserrat Closa, Pedro De March, Marta Figueredo, Josep Font, Angeles Soria

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17 Citations (Scopus)

Abstract

The 1,3-dipolar cycloaddition of cyclic nitrones to several C6 α,β- unsaturated esters and lactones with different functionalities has been studied. All these olefins have shown high stereoselectivity, with a predominance of the exo or endo transition state for the cis or trans dipolarophiles, respectively. The antifacial approach is favoured in the reactions with γ-substituted hexenolides and also with the substituted nitrone 21.
Original languageEnglish
Pages (from-to)16803-16816
JournalTetrahedron
Volume53
Issue number49
DOIs
Publication statusPublished - 8 Dec 1997

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