CXCR4 Expression as a Prognostic Biomarker in Soft Tissue Sarcomas

Anna Virgili, Juliana Salazar, Alberto Gallardo, Antonio López-Pousa, Raúl Terés, Sílvia Bagué Rosell, Caterina Fumagalli, Ramon Mangues, Lorena Alba-Castellón, Ugutz Unzueta Elorza, Isolda Casanova Rigat, Ana Sebio

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Poor long-term survival in localized high-risk soft tissue sarcomas (STSs) of the extremities and trunk highlights the need to identify new prognostic factors. CXCR4 is a chemokine receptor involved in tumor progression, angiogenesis, and metastasis. The aim of this study was to evaluate the association between CXCR4 expression in tumor tissue and survival in STSs patients treated with neoadjuvant therapy. CXCR4 expression was retrospectively determined by immunohistochemical analysis in serial specimens including initial biopsies, tumors post-neoadjuvant treatment, and tumors after relapse. We found that a positive cytoplasmatic expression of CXCR4 in tumors after neoadjuvant treatment was a predictor of poor recurrence-free survival (RFS) (p = 0.003) and overall survival (p = 0.019) in synovial sarcomas. We also found that positive nuclear CXCR4 expression in the initial biopsies was associated with poor RFS (p = 0.022) in undifferentiated pleomorphic sarcomas. In conclusion, our study adds to the evidence that CXCR4 expression in tumor tissue is a promising prognostic factor for STSs.
Original languageEnglish
Article number1195
Number of pages11
JournalDiagnostics
Volume14
Issue number11
DOIs
Publication statusPublished - Jun 2024

Keywords

  • CXCR4
  • Prognostic factor
  • Soft tissue sarcomas
  • Synovial sarcomas
  • Undifferentiated pleomorphic sarcomas
  • undifferentiated pleomorphic sarcomas
  • soft tissue sarcomas
  • synovial sarcomas
  • prognostic factor

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