Cutaneous presentation of chronic lymphocytic leukemia as unique extramedullar involvement in a patient with normal peripheral blood lymphocyte count (monoclonal B-cell lymphocytosis)

Gustavo Tapia, José Luis Mate, María José Fuente, José Tomás Navarro, Maria Teresa Fernández-Figueras, Jordi Juncà, Carlos Ferrándiz, Aurelio Ariza

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5 Citations (Scopus)

Abstract

Skin infiltration by chronic lymphocytic leukemia (CLL) is very rare and almost all reported cases occur in advanced stage. We report a patient with no relevant past medical history who presented with cutaneous erythematous plaques. A punch biopsy showed typical CLL morphologic and immunophenotypic features. Subsequent studies revealed a normal lymphocyte count in peripheral blood, and there was no evidence of lymphadenopathy or organomegaly. Flow cytometry demonstrated a clonal B-cell population both in the bone marrow and peripheral blood (1.60 × 109/l) with a CLL phenotype, but it did not fulfill required criteria for CLL diagnosis. Without cutaneous involvement, this case should be classified as monoclonal B-cell lymphocytosis. © 2013 John Wiley & Sons A/S.
Original languageEnglish
Pages (from-to)740-744
JournalJournal of Cutaneous Pathology
Volume40
Issue number8
DOIs
Publication statusPublished - 1 Aug 2013

Keywords

  • cutaneous lymphoma
  • hematopathology
  • molecular pathology

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