Skin lesions are the most visible and frequent symptoms in lupus erythromatosus (LE). These lesions vary greatly in their clinical as well as microscopic features, which difficults the understanding and study of LE. Most of the patients that express skin disease do not suffer from serious systemic complications, but from important morbidity given the extension, chronicity, chances of scarring and disfigurement that skin lesions may cause. The exact pathogenic mechanisms that induce the development of skin lesions in LE are unknown at present; however, ultraviolet (UV) radiation could play an important role. UV- induced keratinocyte apoptosis as well as proinflammatory stimuli release because of uncomplete apoptotic cell clearance may be the pillars of the etiology of this skin disease. Nonetheless, there are still many questions to answer. The treatment consists of photoprotection, topical administration of corticoids as well as oral administration of antimalarial drugs.
|Publication status||Published - 1 Jan 2010|
- Cutaneous lupus erythromatosus
- Discoid lupus erythromatosus
- Lupus erythromatosus tumidus
- Lupus panniculitis
- Subacute cutaneous lupus erythromatosus