Current trends in the treatment of polycystic ovary syndrome with desire for children

Margalida E. Sastre, Maria O. Prat, Miguel Angel Checa, Ramon C. Carreras

Research output: Contribution to journalReview articleResearchpeer-review

17 Citations (Scopus)


Polycystic ovary syndrome (PCOS), one of the most frequent endocrine diseases, affects approximately 5%-10% of women of childbearing age and constitutes the most common cause of female sterility regardless of the need or not for treatment, a change in lifestyle is essential for the treatment to work and ovulation to be restored. Obesity is the principal reason for modifying lifestyle since its reduction improves ovulation and the capacity for pregnancy and lowers the risk of miscarriage and later complications that may occur during pregnancy (gestational diabetes, pre-eclampsia, etc). When lifestyle modification is not sufficient, the first step in ovulation induction is clomiphene citrate. The second-step recommendation is either exogenous gonadotrophins or laparoscopic ovarian surgery. Recommended third-line treatment is in vitro fertilization. Metformin use in PCOS should be restricted to women with glucose intolerance. © 2009 Sastre et al, publisher and licensee Dove Medical Press Ltd.
Original languageEnglish
Pages (from-to)353-360
JournalTherapeutics and Clinical Risk Management
Issue number1
Publication statusPublished - 1 Dec 2009


  • Clomiphene citrate
  • Letrozole
  • Lifestyle
  • Obesity
  • Polycystic ovarian syndrome
  • Pregnancy


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