Current epidemiology and outcome of infective endocarditis: A multicenter, prospective, cohort study

Patricia Muñoz*, Martha Kestler, Arístides De Alarcón, José María Miro, Javier Bermejo, Hugo Rodríguez-Abella, Maria Carmen Fariñas, Manuel Cobo Belaustegui, Carlos A. Mestres, Pedro Llinares, Miguel Goenaga, Enrique Navas, José Antonio Oteo, Paola Tarabini-Castellani, Emilio Bouza, Fernando Fernández Sánchez, Marian Noureddine, Gabriel Rosas, Javier De La Torre Lima, José AramendiElena Bereciartua, María Victoria Boado, Marta Campaña Lázaro, Josune Goikoetxea, Juan José Goiti, José Luis Hernández, José Ramón Iruretagoyena, Josu Irurzunzuazabal, Inés Martínez, Pedro María Pérez, Regino Rodrí-Guez, Roberto Voces, Ma Victoria García López, Radka Ivanova Georgieva, Manuel Márquez Solero, Isabel Rodríguez Bailón, Josefa Ruiz Morales, Ana María Cuende, Pedro Idígoras, José Antonio Iribarren, Alberto Izaguirre Yarza, Carlos Reviejo, Tomás Echeverría, Eduardo Gaminde, Miguer Angel Goenaga, Ana Fuertes, Rafael Carrasco, Vicente Climent, Patricio Llamas, Esperanza Merino, Joaquín Plazas, Sergio Reus, Nemesio Álvarez, José María Bravo-Ferrer, Dolores Sousa Regueiro, Efrén Sanchez, Laura Castelo, José Cuenca, Enrique Miguez Rey, María Rodríguez Mayo, José Manuel Lomas, Francisco Javier Martínez, Ma Del Mar Alonso, Beatriz Castro, Dá Cil García Marrero, Ma Del Carmen Durán, Ma Antonia Miguel Gómez, Juan La Calzada, Ibrahim Nassar, Antonio Plata Ciezar, José Ma Reguera Iglesias, Víctor Asensi Álvarez, Carlos Costas, Jesús De La Hera, Jonnathan Fernández Suárez, José Manuel García Ruiz, Lisardo Iglesias Fraile, José López Menéndez, Pilar Mencia Bajo, Carlos Morales, Alfonso Moreno Torrico, Carmen Palomo, Francisco Péé Rez, Ángeles Rodríguez, Mauricio Telenti, Manuel Almela, Yolanda Armero, Manuel Azqueta, Ximena Castañeda, Carlos Cervera, Carlos Falces, Cristina García De La Maria, José M. Gatell, Magda Heras, Jaume Llopis Pérez, Francesc Marco, Josemaria Miró, Carlos A. Mestres, Asunción Moreno, Salvador Ninot, José Ramírez, Marta Sitges, Carlos Paré, Juan Manuel Pericás, Alia Eworo, Ana Fernández Cruz, Marcela González Del Vecchio, Víctor González Ramallo, Mercedes Marín, Manuel Martínez-Sellés, Ma Cruz Menárguez, Marta Rodríguez-Créixems, Jorge Rodríguez Roda, Marisol Salas, Antonio Segado, Blanca Pinilla, Ángel Pinto, Maricela Valerio, Eduardo Verde, Isabel Antorrena, José Ma Fraile Vicente, Carlos García Cerrada, Luis García Guereta, Alicia Lorenao Hernández, Alejandro Martín Quirós, Mar Moreno, José Ramón Paño, Ma Angustias Quesada Simón, Mikel Rico, Ma Ángeles Rodríguez Dávila, María Romero, Sandra Rosillo, Alicia Rico Nieto, Ana Arnaiz, José Berrazueta, Sara Bellisco, Raquel Durán, Concepción Fariñas-Álvarez, Carlos Fernández Mazarrasa, Rubén Gómez Izquierdo, Claudia González Rico, José Gutiérrez Díez, Rafael Martín Durán, Marcos Pajarón, José Antonio Parra, Ramón Teira, Jesús Zarauza, Pablo García Pavía, Jesús González, Beatriz Orden, Antonio Ramos, Elena Rodríguez González, Tomasa Centella, José Hermida, José Moya, Pilar Martínez, Enrique Oliva, Alejandro Del Río, Soledad Ruiz, César Martínez, Andrés Nodar, Roberto Pérez, Francisco José Vasallo, Carmen Hidalgo Tenorio, Antonio De Castro, Marina De Cueto, Pastora Gallego, Jesús Rodríguez Baño, Emilio García, Juan Luis Haro, José Antonio Lepe, Francisco López, Rafael Luque, Luis Javier Alonso, José Ramón Blanco, Lara García, Natividad De Benito, Mercé Gurguí, Cristina Pacho, Roser Pericas, Guillem Pons, M. Álvarez, A. L. Fernández, Amparo Martínez, A. Prieto, Benito Regueiro, E. Tijeira, Marino Vega, Andrés Canut Blasco, José Cordo Mollar, Juan Carlos Gainzarain Arana, Oscar García Uriarte, Alejandro Martín López, Zuriñe Ortiz De Zárate, José Antonio Urturi Matos, Ma Belén Nacle, Antonio Sánchez, Luis Vallejo, José Ma Arribas Leal, Elisa García Vázquez, Alicia Hernández Torres, Joaquín Ruiz Gómez, Gonzalo De La Morena Valenzuela, Nicolás Bayón, Ma Dolores Díaz, Darío Durán, Juan Carlos Rodríguez, Antonio Moreno, Ángel Alonso, Javier Aramburu, Felicitas Elena Calvo, Anai Moreno Rodríguez, Paola Tarabini-Castellani

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

Abstract

The aim of the study was to describe the epidemiologic and clinical characteristics and identify the risk factors of short-term and 1-year mortality in a recent cohort of patients with infective endocarditis (IE). From January 2008, multidisciplinary teams have prospectively collected all consecutive cases of IE, diagnosed according to the Duke criteria, in 25 Spanish hospitals. Overall, 1804 patients were diagnosed. The median age was 69 years (interquartile range, 55-77), 68.0% were men, and 37.1% of the cases were nosocomial or health care-related IE. Gram-positive microorganisms accounted for 79.3% of the episodes, followed by Gram-negative (5.2%), fungi (2.4%), anaerobes (0.9%), polymicrobial infections (1.9%), and unknown etiology (9.1%). Heart surgerywas performed in 44.2%, and in-hospital mortality was 28.8%. Risk factors for in-hospital mortality were age, previous heart surgery, cerebrovascular disease, atrial fibrillation, Staphylococcus or Candida etiology, intracardiac complications, heart failure, and septic shock. The 1-year independent risk factors for mortality were age (odds ratio [OR], 1.02), neoplasia (OR, 2.46), renal insufficiency (OR, 1.59), and heart failure (OR, 4.42). Surgery was an independent protective factor for 1-year mortality (OR, 0.44). IE remains a severe disease with a high rate of in-hospital (28.9%) and 1-year mortality (11.2%). Surgery was the only intervention that significantly reduced 1-year mortality.

Original languageEnglish
Article numbere1816
JournalMedicine (United States)
Volume94
Issue number43
DOIs
Publication statusPublished - 2015

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