Current dilemmas in the diagnosis and management of follicular thyroid tumors

Marine Renard, Belén Lloveras, Juana Flores, Jaume Puig, David Benaiges, Antonio Sitges-Serra

    Research output: Contribution to journalArticleResearchpeer-review


    © 2016 Informa UK Limited, trading as Taylor & Francis Group. Follicular carcinoma (FTC) is a relatively uncommon type of differentiated thyroid carcinoma. Guidelines have often dealt with FTC and papillary thyroid cancer as a single disease. Over the last decade, however, a better understanding of these two types of thyroid cancer indicates that they cannot be analysed together. Neither ultrasonography nor fine-needle aspiration cytology can provide a clear distinction between FTC and follicular adenoma. New molecular diagnostic techniques may be used to identify a subpopulation of follicular neoplasms with a low probability of being malignant. Diagnostic surgery—usually hemithyroidectomy- is recommended for most thyroid follicular lesions without a certain preoperative diagnosis. If FTC is diagnosed most—perhaps not all- patients will require a completion thyroidectomy. While widely invasive FTC usually does not pose diagnostic or therapeutic doubts, consensus on the diagnosis of non-invasive follicular lesions is still lacking. Prognosis of FTC is mostly dependent on local invasion and distant metastasis that, in turn, correlate with tumor size.
    Original languageEnglish
    Pages (from-to)379-385
    JournalExpert Review of Endocrinology and Metabolism
    Issue number5
    Publication statusPublished - 2 Sep 2016


    • Bethesda IV
    • follicular
    • management
    • pathology
    • Thyroid cancer


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