Copyright © 2018 John Wiley & Sons, Ltd. Two-dimensional J-resolved (Jres) NMR experiments offer a simple, user-friendly spectral representation where the information of coupling constants and chemical shifts are separated into two orthogonal frequency axis. Since its initial proposal 40 years ago, Jres has been the focus of considerable interest both in improving the basic pulse sequence and in its successful application to a wide range of studies. Here, the latest developments in the design of novel Jres pulse schemes are reviewed, mainly focusing on obtaining pure absorption lineshapes, minimizing strong coupling artifacts, and also optimizing sensitivity and experimental measurements. A discussion of several Jres versions for the accurate measurement of a different number of homonuclear (JHH) and heteronuclear (JCH) coupling constants is presented, accompanied by some illustrative examples.
|Journal||Magnetic Resonance in Chemistry|
|Publication status||Published - 1 Apr 2018|
- J-resolved HSQC
- proton–carbon coupling constants
- proton–proton coupling constants
- residual dipolar couplings