Crystal structure of thioflavin-T and its binding to amyloid fibrils: Insights at the molecular level

Cristina Rodríguez-Rodríguez, Albert Rimola, Luis Rodríguez-Santiago, Piero Ugliengo, Ángel Álvarez-Larena, Hugo Gutiérrez-De-Terán, Mariona Sodupe, Pilar González-Duarte

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61 Citations (Scopus)

Abstract

Combining X-ray data on thioflavin-T and theoretical calculations on its binding to a peptide model for Aβ1-42 fibrils gives evidence of main stabilizing interactions, which influence the dihedral angle between the two moieties of thioflavin-T and thereby its fluorescence properties; these results shed new light on possible strategies for the design of dyes to bind amyloid fibrils more specifically. © 2010 The Royal Society of Chemistry.
Original languageEnglish
Pages (from-to)1156-1158
JournalChemical Communications
Volume46
Issue number7
DOIs
Publication statusPublished - 15 Feb 2010

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