TY - JOUR
T1 - Crystal structure of thioflavin-T and its binding to amyloid fibrils: Insights at the molecular level
AU - Rodríguez-Rodríguez, Cristina
AU - Rimola, Albert
AU - Rodríguez-Santiago, Luis
AU - Ugliengo, Piero
AU - Álvarez-Larena, Ángel
AU - Gutiérrez-De-Terán, Hugo
AU - Sodupe, Mariona
AU - González-Duarte, Pilar
PY - 2010/2/15
Y1 - 2010/2/15
N2 - Combining X-ray data on thioflavin-T and theoretical calculations on its binding to a peptide model for Aβ1-42 fibrils gives evidence of main stabilizing interactions, which influence the dihedral angle between the two moieties of thioflavin-T and thereby its fluorescence properties; these results shed new light on possible strategies for the design of dyes to bind amyloid fibrils more specifically. © 2010 The Royal Society of Chemistry.
AB - Combining X-ray data on thioflavin-T and theoretical calculations on its binding to a peptide model for Aβ1-42 fibrils gives evidence of main stabilizing interactions, which influence the dihedral angle between the two moieties of thioflavin-T and thereby its fluorescence properties; these results shed new light on possible strategies for the design of dyes to bind amyloid fibrils more specifically. © 2010 The Royal Society of Chemistry.
U2 - 10.1039/b912396b
DO - 10.1039/b912396b
M3 - Article
SN - 1359-7345
VL - 46
SP - 1156
EP - 1158
JO - Chemical Communications
JF - Chemical Communications
IS - 7
ER -