TY - JOUR
T1 - Cryptococcus gattii: In vitro susceptibility to the new antifungal albaconazole versus fluconazole and voriconazole
AU - Morera-López, Yolanda
AU - Torres-Rodríguez, Josep M.
AU - Jiménez-Cabello, Teresa
AU - Baró-Tomás, Teresa
PY - 2005/9/1
Y1 - 2005/9/1
N2 - Minimal inhibitory concentrations (MIC) and minimal fungicidal activity of albaconazole, voriconazole and fluconazole against 55 strains of Cryptococcus gattii, clinically or environmentally isolated in Spain and some Latin American countries, were assessed. By means of the microbroth method (National Committee for Clinical Laboratory Standards; document M27-A2), the geometric mean value for fluconazole was 5.01 μg/ml; however, MIC for 12.7% of isolates ranged from 16 to 32 μg/ml, suggesting increased resistance against fluconazole. Geometric mean values of 0.02 and 0.03 μg/ml for albaconazole and voriconazole, respectively, were found, indicating not only a higher susceptibility to these new azoles but also a better performance of albaconazole (P = 0.003). Minimal fungicidal concentrations were also very low for albaconazole and voriconazole (P<0.001; geometric mean values of 0.023 μg/ml and 0.07 μg/ml, respectively). Both azoles may be good alternatives for the treatment of C. gattii cryptococcosis. © 2005 ISHAM.
AB - Minimal inhibitory concentrations (MIC) and minimal fungicidal activity of albaconazole, voriconazole and fluconazole against 55 strains of Cryptococcus gattii, clinically or environmentally isolated in Spain and some Latin American countries, were assessed. By means of the microbroth method (National Committee for Clinical Laboratory Standards; document M27-A2), the geometric mean value for fluconazole was 5.01 μg/ml; however, MIC for 12.7% of isolates ranged from 16 to 32 μg/ml, suggesting increased resistance against fluconazole. Geometric mean values of 0.02 and 0.03 μg/ml for albaconazole and voriconazole, respectively, were found, indicating not only a higher susceptibility to these new azoles but also a better performance of albaconazole (P = 0.003). Minimal fungicidal concentrations were also very low for albaconazole and voriconazole (P<0.001; geometric mean values of 0.023 μg/ml and 0.07 μg/ml, respectively). Both azoles may be good alternatives for the treatment of C. gattii cryptococcosis. © 2005 ISHAM.
KW - Albaconazole
KW - Cryptococcus gatti
KW - Fluconazole
KW - In vitro susceptibility
KW - Voricinazole
U2 - https://doi.org/10.1080/13693780400029528
DO - https://doi.org/10.1080/13693780400029528
M3 - Article
VL - 43
SP - 505
EP - 510
ER -