Cryptic IGH/BCL2 rearrangements with variant FISH patterns in follicular lymphoma

Cristina Baró; Blanca Espinet; Marta Salido; Mar García; Blanca Sánchez; Lourdes Florensa; Beatriz Bellosillo; Sergi Serrano; Francesc Solé

doi:10.1016/j.leukres.2010.09.011

Cryptic IGH/BCL2 rearrangements with variant FISH patterns in follicular lymphoma

Cristina Baró, Blanca Espinet, Marta Salido, Mar García, Blanca Sánchez, Lourdes Florensa, Beatriz Bellosillo, Sergi Serrano, Francesc Solé

Department of Morphological Sciences

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

Abstract

Follicular lymphoma (FL) is one of the most common non-Hodgkin lymphomas (NHL). Translocation t(14;18)(q32;q21) involving IGH and BCL2 genes represents its genetic hallmark. We present six cases of a series of 75 well diagnosed FL patients in which variant fluorescence in situ hybridization (FISH) patterns for this rearrangement were found. Moreover, G-banding cytogenetics and polymerase chain reaction (PCR) methods were unable to detect t(14;18)(q32;q21). According to our results, FISH is the best technique to define variant rearrangements of IGH/. BCL2 genes and is important to detect it in cases with non-conclusive FL characteristics to avoid misdiagnosis with other NHL. © 2010 Elsevier Ltd.

Original language	English
Pages (from-to)	256-259
Journal	Leukemia Research
Volume	35
Issue number	2
DOIs	https://doi.org/10.1016/j.leukres.2010.09.011
Publication status	Published - 1 Feb 2011

Keywords

Cytogenetics
FISH
Follicular lymphoma
PCR

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title = "Cryptic IGH/BCL2 rearrangements with variant FISH patterns in follicular lymphoma",

abstract = "Follicular lymphoma (FL) is one of the most common non-Hodgkin lymphomas (NHL). Translocation t(14;18)(q32;q21) involving IGH and BCL2 genes represents its genetic hallmark. We present six cases of a series of 75 well diagnosed FL patients in which variant fluorescence in situ hybridization (FISH) patterns for this rearrangement were found. Moreover, G-banding cytogenetics and polymerase chain reaction (PCR) methods were unable to detect t(14;18)(q32;q21). According to our results, FISH is the best technique to define variant rearrangements of IGH/. BCL2 genes and is important to detect it in cases with non-conclusive FL characteristics to avoid misdiagnosis with other NHL. {\textcopyright} 2010 Elsevier Ltd.",

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T1 - Cryptic IGH/BCL2 rearrangements with variant FISH patterns in follicular lymphoma

AU - Baró, Cristina

AU - Espinet, Blanca

AU - Salido, Marta

AU - García, Mar

AU - Sánchez, Blanca

AU - Florensa, Lourdes

AU - Bellosillo, Beatriz

AU - Serrano, Sergi

AU - Solé, Francesc

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Follicular lymphoma (FL) is one of the most common non-Hodgkin lymphomas (NHL). Translocation t(14;18)(q32;q21) involving IGH and BCL2 genes represents its genetic hallmark. We present six cases of a series of 75 well diagnosed FL patients in which variant fluorescence in situ hybridization (FISH) patterns for this rearrangement were found. Moreover, G-banding cytogenetics and polymerase chain reaction (PCR) methods were unable to detect t(14;18)(q32;q21). According to our results, FISH is the best technique to define variant rearrangements of IGH/. BCL2 genes and is important to detect it in cases with non-conclusive FL characteristics to avoid misdiagnosis with other NHL. © 2010 Elsevier Ltd.

AB - Follicular lymphoma (FL) is one of the most common non-Hodgkin lymphomas (NHL). Translocation t(14;18)(q32;q21) involving IGH and BCL2 genes represents its genetic hallmark. We present six cases of a series of 75 well diagnosed FL patients in which variant fluorescence in situ hybridization (FISH) patterns for this rearrangement were found. Moreover, G-banding cytogenetics and polymerase chain reaction (PCR) methods were unable to detect t(14;18)(q32;q21). According to our results, FISH is the best technique to define variant rearrangements of IGH/. BCL2 genes and is important to detect it in cases with non-conclusive FL characteristics to avoid misdiagnosis with other NHL. © 2010 Elsevier Ltd.

KW - Cytogenetics

KW - FISH

KW - Follicular lymphoma

KW - PCR

U2 - 10.1016/j.leukres.2010.09.011

DO - 10.1016/j.leukres.2010.09.011

M3 - Article

SN - 0145-2126

VL - 35

SP - 256

EP - 259

JO - Leukemia Research

JF - Leukemia Research

IS - 2

ER -

Cryptic IGH/BCL2 rearrangements with variant FISH patterns in follicular lymphoma

Abstract

Keywords

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