Cryptic IGH/BCL2 rearrangements with variant FISH patterns in follicular lymphoma

Cristina Baró, Blanca Espinet, Marta Salido, Mar García, Blanca Sánchez, Lourdes Florensa, Beatriz Bellosillo, Sergi Serrano, Francesc Solé

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Abstract

Follicular lymphoma (FL) is one of the most common non-Hodgkin lymphomas (NHL). Translocation t(14;18)(q32;q21) involving IGH and BCL2 genes represents its genetic hallmark. We present six cases of a series of 75 well diagnosed FL patients in which variant fluorescence in situ hybridization (FISH) patterns for this rearrangement were found. Moreover, G-banding cytogenetics and polymerase chain reaction (PCR) methods were unable to detect t(14;18)(q32;q21). According to our results, FISH is the best technique to define variant rearrangements of IGH/. BCL2 genes and is important to detect it in cases with non-conclusive FL characteristics to avoid misdiagnosis with other NHL. © 2010 Elsevier Ltd.
Original languageEnglish
Pages (from-to)256-259
JournalLeukemia Research
Volume35
Issue number2
DOIs
Publication statusPublished - 1 Feb 2011

Keywords

  • Cytogenetics
  • FISH
  • Follicular lymphoma
  • PCR

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    Baró, C., Espinet, B., Salido, M., García, M., Sánchez, B., Florensa, L., Bellosillo, B., Serrano, S., & Solé, F. (2011). Cryptic IGH/BCL2 rearrangements with variant FISH patterns in follicular lymphoma. Leukemia Research, 35(2), 256-259. https://doi.org/10.1016/j.leukres.2010.09.011