Abstract
© 2018 - IOS Press and the authors. All rights reserved. Cardiovascular disease resulting from oxidative stress and inflammation can exacerbate Alzheimer's disease. This brief report provides the first evidence of compromised small peripheral mesenteric resistance artery (MRA) properties in 15-month-old 3xTg-AD mice. Females showed worse physiologically relevant MRA structural (increased passive external and internal diameters, cross sectional area) and functional (increased active internal diameters) alterations suggesting sex-dependent dysfunctions. At both physiological and high intraluminal pressures, vascular alterations correlated with the anxious-like behavioral profile, in a sex-dependent manner. Finally, the results unveil a crosstalk between peripheral small vessel properties and behavior in both 3xTg-AD mice and age-matched counterparts with normal aging.
Original language | English |
---|---|
Pages (from-to) | 1531-1538 |
Journal | Journal of Alzheimer's Disease |
Volume | 62 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Jan 2018 |
Keywords
- 3×Tg-AD mice
- Alzheimer's disease
- aging
- cardiovascular disease
- emerging concepts
- gender medicine
- oxidative stress
- peripheral inflammation
- small mesenteric resistance arteries
- vascular remodeling