TY - JOUR
T1 - Crosstalk between Peripheral Small Vessel Properties and Anxious-like Profiles: Sex, Genotype, and Interaction Effects in Mice with Normal Aging and 3×Tg-AD mice at Advanced Stages of Disease
AU - Jiménez-Altayó, Francesc
AU - Sánchez-Ventura, Judith
AU - Vila, Elisabet
AU - Giménez-Llort, Lydia
PY - 2018/1/1
Y1 - 2018/1/1
N2 - © 2018 - IOS Press and the authors. All rights reserved. Cardiovascular disease resulting from oxidative stress and inflammation can exacerbate Alzheimer's disease. This brief report provides the first evidence of compromised small peripheral mesenteric resistance artery (MRA) properties in 15-month-old 3xTg-AD mice. Females showed worse physiologically relevant MRA structural (increased passive external and internal diameters, cross sectional area) and functional (increased active internal diameters) alterations suggesting sex-dependent dysfunctions. At both physiological and high intraluminal pressures, vascular alterations correlated with the anxious-like behavioral profile, in a sex-dependent manner. Finally, the results unveil a crosstalk between peripheral small vessel properties and behavior in both 3xTg-AD mice and age-matched counterparts with normal aging.
AB - © 2018 - IOS Press and the authors. All rights reserved. Cardiovascular disease resulting from oxidative stress and inflammation can exacerbate Alzheimer's disease. This brief report provides the first evidence of compromised small peripheral mesenteric resistance artery (MRA) properties in 15-month-old 3xTg-AD mice. Females showed worse physiologically relevant MRA structural (increased passive external and internal diameters, cross sectional area) and functional (increased active internal diameters) alterations suggesting sex-dependent dysfunctions. At both physiological and high intraluminal pressures, vascular alterations correlated with the anxious-like behavioral profile, in a sex-dependent manner. Finally, the results unveil a crosstalk between peripheral small vessel properties and behavior in both 3xTg-AD mice and age-matched counterparts with normal aging.
KW - 3×Tg-AD mice
KW - Alzheimer's disease
KW - aging
KW - cardiovascular disease
KW - emerging concepts
KW - gender medicine
KW - oxidative stress
KW - peripheral inflammation
KW - small mesenteric resistance arteries
KW - vascular remodeling
U2 - 10.3233/JAD-171019
DO - 10.3233/JAD-171019
M3 - Article
C2 - 29504535
SN - 1387-2877
VL - 62
SP - 1531
EP - 1538
JO - Journal of Alzheimer's disease (Print)
JF - Journal of Alzheimer's disease (Print)
IS - 4
ER -
