Crosstalk between Peripheral Small Vessel Properties and Anxious-like Profiles: Sex, Genotype, and Interaction Effects in Mice with Normal Aging and 3×Tg-AD mice at Advanced Stages of Disease

Francesc Jiménez-Altayó; Judith Sánchez-Ventura; Elisabet Vila; Lydia Giménez-Llort

doi:10.3233/JAD-171019

Crosstalk between Peripheral Small Vessel Properties and Anxious-like Profiles: Sex, Genotype, and Interaction Effects in Mice with Normal Aging and 3×Tg-AD mice at Advanced Stages of Disease

Francesc Jiménez-Altayó, Judith Sánchez-Ventura, Elisabet Vila, Lydia Giménez-Llort

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Abstract

© 2018 - IOS Press and the authors. All rights reserved. Cardiovascular disease resulting from oxidative stress and inflammation can exacerbate Alzheimer's disease. This brief report provides the first evidence of compromised small peripheral mesenteric resistance artery (MRA) properties in 15-month-old 3xTg-AD mice. Females showed worse physiologically relevant MRA structural (increased passive external and internal diameters, cross sectional area) and functional (increased active internal diameters) alterations suggesting sex-dependent dysfunctions. At both physiological and high intraluminal pressures, vascular alterations correlated with the anxious-like behavioral profile, in a sex-dependent manner. Finally, the results unveil a crosstalk between peripheral small vessel properties and behavior in both 3xTg-AD mice and age-matched counterparts with normal aging.

Original language	English
Pages (from-to)	1531-1538
Journal	Journal of Alzheimer's Disease
Volume	62
Issue number	4
DOIs	https://doi.org/10.3233/JAD-171019
Publication status	Published - 1 Jan 2018

Keywords

3×Tg-AD mice
Alzheimer's disease
aging
cardiovascular disease
emerging concepts
gender medicine
oxidative stress
peripheral inflammation
small mesenteric resistance arteries
vascular remodeling

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10.3233/JAD-171019

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@article{82510722b89f42e88b59521e04e260ab,

title = "Crosstalk between Peripheral Small Vessel Properties and Anxious-like Profiles: Sex, Genotype, and Interaction Effects in Mice with Normal Aging and 3×Tg-AD mice at Advanced Stages of Disease",

abstract = "{\textcopyright} 2018 - IOS Press and the authors. All rights reserved. Cardiovascular disease resulting from oxidative stress and inflammation can exacerbate Alzheimer's disease. This brief report provides the first evidence of compromised small peripheral mesenteric resistance artery (MRA) properties in 15-month-old 3xTg-AD mice. Females showed worse physiologically relevant MRA structural (increased passive external and internal diameters, cross sectional area) and functional (increased active internal diameters) alterations suggesting sex-dependent dysfunctions. At both physiological and high intraluminal pressures, vascular alterations correlated with the anxious-like behavioral profile, in a sex-dependent manner. Finally, the results unveil a crosstalk between peripheral small vessel properties and behavior in both 3xTg-AD mice and age-matched counterparts with normal aging.",

keywords = "3×Tg-AD mice, Alzheimer's disease, aging, cardiovascular disease, emerging concepts, gender medicine, oxidative stress, peripheral inflammation, small mesenteric resistance arteries, vascular remodeling",

author = "Francesc Jim{\'e}nez-Altay{\'o} and Judith S{\'a}nchez-Ventura and Elisabet Vila and Lydia Gim{\'e}nez-Llort",

year = "2018",

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doi = "10.3233/JAD-171019",

language = "English",

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Crosstalk between Peripheral Small Vessel Properties and Anxious-like Profiles: Sex, Genotype, and Interaction Effects in Mice with Normal Aging and 3×Tg-AD mice at Advanced Stages of Disease. / Jiménez-Altayó, Francesc; Sánchez-Ventura, Judith; Vila, Elisabet; Giménez-Llort, Lydia.

In: Journal of Alzheimer's Disease, Vol. 62, No. 4, 01.01.2018, p. 1531-1538.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Crosstalk between Peripheral Small Vessel Properties and Anxious-like Profiles: Sex, Genotype, and Interaction Effects in Mice with Normal Aging and 3×Tg-AD mice at Advanced Stages of Disease

AU - Jiménez-Altayó, Francesc

AU - Sánchez-Ventura, Judith

AU - Vila, Elisabet

AU - Giménez-Llort, Lydia

PY - 2018/1/1

Y1 - 2018/1/1

N2 - © 2018 - IOS Press and the authors. All rights reserved. Cardiovascular disease resulting from oxidative stress and inflammation can exacerbate Alzheimer's disease. This brief report provides the first evidence of compromised small peripheral mesenteric resistance artery (MRA) properties in 15-month-old 3xTg-AD mice. Females showed worse physiologically relevant MRA structural (increased passive external and internal diameters, cross sectional area) and functional (increased active internal diameters) alterations suggesting sex-dependent dysfunctions. At both physiological and high intraluminal pressures, vascular alterations correlated with the anxious-like behavioral profile, in a sex-dependent manner. Finally, the results unveil a crosstalk between peripheral small vessel properties and behavior in both 3xTg-AD mice and age-matched counterparts with normal aging.

AB - © 2018 - IOS Press and the authors. All rights reserved. Cardiovascular disease resulting from oxidative stress and inflammation can exacerbate Alzheimer's disease. This brief report provides the first evidence of compromised small peripheral mesenteric resistance artery (MRA) properties in 15-month-old 3xTg-AD mice. Females showed worse physiologically relevant MRA structural (increased passive external and internal diameters, cross sectional area) and functional (increased active internal diameters) alterations suggesting sex-dependent dysfunctions. At both physiological and high intraluminal pressures, vascular alterations correlated with the anxious-like behavioral profile, in a sex-dependent manner. Finally, the results unveil a crosstalk between peripheral small vessel properties and behavior in both 3xTg-AD mice and age-matched counterparts with normal aging.

KW - 3×Tg-AD mice

KW - Alzheimer's disease

KW - aging

KW - cardiovascular disease

KW - emerging concepts

KW - gender medicine

KW - oxidative stress

KW - peripheral inflammation

KW - small mesenteric resistance arteries

KW - vascular remodeling

U2 - 10.3233/JAD-171019

DO - 10.3233/JAD-171019

M3 - Article

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VL - 62

SP - 1531

EP - 1538

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

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