Crosstalk between Peripheral Small Vessel Properties and Anxious-like Profiles: Sex, Genotype, and Interaction Effects in Mice with Normal Aging and 3×Tg-AD mice at Advanced Stages of Disease

Francesc Jiménez-Altayó, Judith Sánchez-Ventura, Elisabet Vila, Lydia Giménez-Llort

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

© 2018 - IOS Press and the authors. All rights reserved. Cardiovascular disease resulting from oxidative stress and inflammation can exacerbate Alzheimer's disease. This brief report provides the first evidence of compromised small peripheral mesenteric resistance artery (MRA) properties in 15-month-old 3xTg-AD mice. Females showed worse physiologically relevant MRA structural (increased passive external and internal diameters, cross sectional area) and functional (increased active internal diameters) alterations suggesting sex-dependent dysfunctions. At both physiological and high intraluminal pressures, vascular alterations correlated with the anxious-like behavioral profile, in a sex-dependent manner. Finally, the results unveil a crosstalk between peripheral small vessel properties and behavior in both 3xTg-AD mice and age-matched counterparts with normal aging.
Original languageEnglish
Pages (from-to)1531-1538
JournalJournal of Alzheimer's Disease
Volume62
Issue number4
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • 3×Tg-AD mice
  • Alzheimer's disease
  • aging
  • cardiovascular disease
  • emerging concepts
  • gender medicine
  • oxidative stress
  • peripheral inflammation
  • small mesenteric resistance arteries
  • vascular remodeling

Fingerprint Dive into the research topics of 'Crosstalk between Peripheral Small Vessel Properties and Anxious-like Profiles: Sex, Genotype, and Interaction Effects in Mice with Normal Aging and 3×Tg-AD mice at Advanced Stages of Disease'. Together they form a unique fingerprint.

Cite this