Critical role of neutrophils in eliminating Listeria monocytogenes from the central nervous system during experimental murine listeriosis

Santiago López, Alberto Jesús Marco, Neus Prats, Charles J. Czuprynski

    Research output: Contribution to journalArticleResearchpeer-review

    24 Citations (Scopus)

    Abstract

    Neutrophils are the main inflammatory cell present in lesions involving the central nervous system (CNS) during human and murine listeriosis. In this study, administration of the neutrophil-depleting monoclonal antibody RB6-8C5 during experimental murine listeriosis facilitated the multiplication of Listeria monocytogenes in the CNS. These data suggest that neutrophils play a key role in eliminating bacteria that gain access to the CNS compartment. In addition, we provide evidence that their migration into the CNS may be necessary for the subsequent recruitment of macrophages and activated lymphocytes.
    Original languageEnglish
    Pages (from-to)4789-4791
    JournalInfection and Immunity
    Volume68
    Issue number8
    DOIs
    Publication statusPublished - 12 Aug 2000

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