CraA, a major facilitator superfamily efflux pump associated with chloramphenicol resistance in Acinetobacter baumannii

I. Roca, S. Marti, P. Espinal, P. Martínez, I. Gibert, J. Vila

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)

Abstract

Acinetobacter baumannii has been increasingly associated with hospital-acquired infections, and the presence of multidrug resistance strains is of great concern to clinicians. A. baumannii is thought to possess a great deal of intrinsic resistance to several antimicrobial agents, including chloramphenicol, although the mechanisms involved in such resistance are not well understood. In this work, we have identified a major facilitator superfamily efflux pump present in most A. baumannii strains, displaying strong substrate specificity toward chloramphenicol. Copyright © 2009, American Society for Microbiology. All Rights Reserved.
Original languageEnglish
Pages (from-to)4013-4014
JournalAntimicrobial Agents and Chemotherapy
Volume53
DOIs
Publication statusPublished - 21 Sep 2009

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