Abstract
The ESI-MS and EPR results obtained during the study of systems containing vanadium-protein adducts have been explained integrating the spectrometric and spectroscopic responses with molecular modelling simulations. The representative systems formed by the potential antibacterial drug [VIVO(nalidixato)2(H2O)] with lysozyme and cytochrome c were fully characterized, interpreting the ESI-MS and EPR signals as the result of covalent and non-covalent binding. This behaviour should be considered for all metal-protein systems, and instrumental techniques-if necessary-should be coupled with modelling to achieve full characterization of the types of binding.
Original language | English |
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Pages (from-to) | 1189-1196 |
Number of pages | 8 |
Journal | Inorganic Chemistry Frontiers |
Volume | 8 |
Issue number | 5 |
DOIs | |
Publication status | Published - 7 Mar 2021 |