Covalent and non-covalent binding in vanadium-protein adducts

Valeria Ugone, Daniele Sanna, Simone Ruggiu, Giuseppe Sciortino*, Eugenio Garribba*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)
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Abstract

The ESI-MS and EPR results obtained during the study of systems containing vanadium-protein adducts have been explained integrating the spectrometric and spectroscopic responses with molecular modelling simulations. The representative systems formed by the potential antibacterial drug [VIVO(nalidixato)2(H2O)] with lysozyme and cytochrome c were fully characterized, interpreting the ESI-MS and EPR signals as the result of covalent and non-covalent binding. This behaviour should be considered for all metal-protein systems, and instrumental techniques-if necessary-should be coupled with modelling to achieve full characterization of the types of binding.

Original languageEnglish
Pages (from-to)1189-1196
Number of pages8
JournalInorganic Chemistry Frontiers
Volume8
Issue number5
DOIs
Publication statusPublished - 7 Mar 2021

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