Cost-effectiveness of Sativex in multiple sclerosis spasticity: New data and application to Italy

John Slof, Leonardo Ruiz, Carlos Vila

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)


© Informa UK, Ltd. Multiple sclerosis (MS) is a chronic progressive disease that carries a high socioeconomic burden. Spasticity (rigidity and spasms) is common in MS and contributes to MS-related disability. This study aims to evaluate the cost-effectiveness of Sativex® (9-delta-tetrahydrocannabinol plus cannabidiol oromucosal spray) when used as add-on therapy for management of resistant MS-related spasticity in the context of the Italian healthcare system. A previously published Markov model-based analysis for the German and Spanish context was replicated, adapting it to the Italian setting. Model parameters were updated to reflect recent findings about MS-related spasticity and use of Sativex in daily clinical practice. The base case incremental cost-effectiveness ratio for Sativex use in Italy over a 5-year period was estimated to be €4968 per quality-adjusted life-year gained (year of costing: 2013). Sativex remained an efficient option in the Italian healthcare context-below the commonly accepted incremental threshold of €30,000 per quality-adjusted life-year gained-when deterministic and probabilistic sensitivity analyses were conducted. Sativex can be regarded as a cost-effective treatment option for patients with MS-related spasticity in Italy.
Original languageEnglish
Pages (from-to)379-391
JournalExpert Review of Pharmacoeconomics and Outcomes Research
Issue number3
Publication statusPublished - 1 Jun 2015


  • cost-effectiveness
  • Italy
  • multiple sclerosis
  • Sativex
  • spasticity


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