Cortical spreading depolarization phenomena in patients with traumatic and ischemic brain injuries: Results of a pilot study

M. Sueiras, J. Sahuquillo, B. García-López, T. Sánchez-Guerrero, M. A. Poca, E. Santamarina, M. Riveiro, M. Fabricius, A. J. Strong

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1 Citation (Scopus)

Abstract

© 2013 Elsevier España, S.L.U. and SEMICYUC. Objectives: To determine the frequency and duration of cortical spreading depolarization (CSD) and CSD-like episodes in patients with traumatic brain injury (TBI) and malignant middle cerebral artery infarction (MMCAI) requiring craniotomy. Design: A descriptive observational study was carried out during 19 months. Setting: Neurocritical patients. Patients: Sixteen patients were included: 9 with MMCAI and 7 with moderate or severe TBI, requiring surgical treatment. Interventions: A 6-electrode subdural electrocorticographic (ECoG) strip was placed onto the perilesional cortex. Main variables of interest: An analysis was made of the time profile and the number and duration of CSD and CSD-like episodes recorded from the ECoGs. Results: Of the 16 patients enrolled, 9 presented episodes of CSD or CSD-like phenomena, of highly variable frequency and duration. Conclusions: Episodes of CSD and CSD-like phenomena are frequently detected in the ischemic penumbra and/or traumatic cortical regions of patients with MMCAI who require decompressive craniectomy or of patients with contusional TBI.
Original languageEnglish
Pages (from-to)413-421
JournalMedicina Intensiva
Volume38
DOIs
Publication statusPublished - 1 Oct 2014

Keywords

  • Brain metabolism
  • Brain tissue oxygen pressure
  • Cortical spreading depolarization
  • Electrocorticography
  • Malignant middle cerebral artery infarction
  • Microdialysis
  • Traumatic brain injury

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