Cortical microstructural changes along the Alzheimer's disease continuum

Victor Montal; Eduard Vilaplana; Daniel Alcolea; Jordi Pegueroles; Ofer Pasternak; Sofia González-Ortiz; Jordi Clarimón; María Carmona-Iragui; Ignacio Illán-Gala; Estrella Morenas-Rodríguez; Roser Ribosa-Nogué; Isabel Sala; María Belén Sánchez-Saudinós; Maite García-Sebastian; Jorge Villanúa; Andrea Izagirre; Ainara Estanga; Mirian Ecay-Torres; Ane Iriondo; Montserrat Clerigue; Mikel Tainta; Ana Pozueta; Andrea González; Eloy Martínez-Heras; Sara Llufriu; Rafael Blesa; Pascual Sanchez-Juan; Pablo Martínez-Lage; Alberto Lleó; Juan Fortea

doi:10.1016/j.jalz.2017.09.013

Cortical microstructural changes along the Alzheimer's disease continuum

Victor Montal, Eduard Vilaplana, Daniel Alcolea, Jordi Pegueroles, Ofer Pasternak, Sofia González-Ortiz, Jordi Clarimón, María Carmona-Iragui, Ignacio Illán-Gala, Estrella Morenas-Rodríguez, Roser Ribosa-Nogué, Isabel Sala, María Belén Sánchez-Saudinós, Maite García-Sebastian, Jorge Villanúa, Andrea Izagirre, Ainara Estanga, Mirian Ecay-Torres, Ane Iriondo, Montserrat ClerigueMikel Tainta, Ana Pozueta, Andrea González, Eloy Martínez-Heras, Sara Llufriu, Rafael Blesa, Pascual Sanchez-Juan, Pablo Martínez-Lage, Alberto Lleó, Juan Fortea

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

67 Citations (Scopus)

Abstract

© 2017 the Alzheimer's Association Introduction: Cortical mean diffusivity (MD) and free water fraction (FW) changes are proposed biomarkers for Alzheimer's disease (AD). Methods: We included healthy control subjects (N = 254), mild cognitive impairment (N = 41), and AD dementia (N = 31) patients. Participants underwent a lumbar puncture and a 3 T magnetic resonance imaging. Healthy control subjects were classified following National Institute on Aging-Alzheimer's Association stages (stage 0, N = 220; stage 1, N = 25; and stage 2/3, N = 9). We assessed the cortical MD, cortical FW, and cortical thickness (CTh) changes along the AD continuum. Results: Microstructural and macrostructural changes show a biphasic trajectory. Stage 1 subjects showed increased CTh and decreased MD and FW with respect the stage 0 subjects. Stage 2/3 subjects showed decreased CTh and increased cortical MD and FW, changes that were more widespread in symptomatic stages. Discussion: These results support a biphasic model of changes in AD, which could affect the selection of patients for clinical trials and the use of magnetic resonance imaging as a surrogate marker of disease modification.

Original language	English
Pages (from-to)	340-351
Journal	Alzheimer's and Dementia
Volume	14
Issue number	3
DOIs	https://doi.org/10.1016/j.jalz.2017.09.013
Publication status	Published - 1 Mar 2018

Keywords

Alzheimer's disease continuum
Amyloid
Biomarkers
CSF
Cortical microstructure
MRI
Tau

Access to Document

10.1016/j.jalz.2017.09.013

Cite this

Montal, V., Vilaplana, E., Alcolea, D., Pegueroles, J., Pasternak, O., González-Ortiz, S., Clarimón, J., Carmona-Iragui, M., Illán-Gala, I., Morenas-Rodríguez, E., Ribosa-Nogué, R., Sala, I., Sánchez-Saudinós, M. B., García-Sebastian, M., Villanúa, J., Izagirre, A., Estanga, A., Ecay-Torres, M., Iriondo, A., ... Fortea, J. (2018). Cortical microstructural changes along the Alzheimer's disease continuum. Alzheimer's and Dementia, 14(3), 340-351. https://doi.org/10.1016/j.jalz.2017.09.013

@article{4bce2195093344a3b33b89f55ebbc799,

title = "Cortical microstructural changes along the Alzheimer's disease continuum",

abstract = "{\textcopyright} 2017 the Alzheimer's Association Introduction: Cortical mean diffusivity (MD) and free water fraction (FW) changes are proposed biomarkers for Alzheimer's disease (AD). Methods: We included healthy control subjects (N = 254), mild cognitive impairment (N = 41), and AD dementia (N = 31) patients. Participants underwent a lumbar puncture and a 3 T magnetic resonance imaging. Healthy control subjects were classified following National Institute on Aging-Alzheimer's Association stages (stage 0, N = 220; stage 1, N = 25; and stage 2/3, N = 9). We assessed the cortical MD, cortical FW, and cortical thickness (CTh) changes along the AD continuum. Results: Microstructural and macrostructural changes show a biphasic trajectory. Stage 1 subjects showed increased CTh and decreased MD and FW with respect the stage 0 subjects. Stage 2/3 subjects showed decreased CTh and increased cortical MD and FW, changes that were more widespread in symptomatic stages. Discussion: These results support a biphasic model of changes in AD, which could affect the selection of patients for clinical trials and the use of magnetic resonance imaging as a surrogate marker of disease modification.",

keywords = "Alzheimer's disease continuum, Amyloid, Biomarkers, CSF, Cortical microstructure, MRI, Tau",

author = "Victor Montal and Eduard Vilaplana and Daniel Alcolea and Jordi Pegueroles and Ofer Pasternak and Sofia Gonz{\'a}lez-Ortiz and Jordi Clarim{\'o}n and Mar{\'i}a Carmona-Iragui and Ignacio Ill{\'a}n-Gala and Estrella Morenas-Rodr{\'i}guez and Roser Ribosa-Nogu{\'e} and Isabel Sala and S{\'a}nchez-Saudin{\'o}s, {Mar{\'i}a Bel{\'e}n} and Maite Garc{\'i}a-Sebastian and Jorge Villan{\'u}a and Andrea Izagirre and Ainara Estanga and Mirian Ecay-Torres and Ane Iriondo and Montserrat Clerigue and Mikel Tainta and Ana Pozueta and Andrea Gonz{\'a}lez and Eloy Mart{\'i}nez-Heras and Sara Llufriu and Rafael Blesa and Pascual Sanchez-Juan and Pablo Mart{\'i}nez-Lage and Alberto Lle{\'o} and Juan Fortea",

year = "2018",

month = mar,

day = "1",

doi = "10.1016/j.jalz.2017.09.013",

language = "English",

volume = "14",

pages = "340--351",

number = "3",

}

Montal, V, Vilaplana, E, Alcolea, D, Pegueroles, J, Pasternak, O, González-Ortiz, S, Clarimón, J, Carmona-Iragui, M, Illán-Gala, I, Morenas-Rodríguez, E, Ribosa-Nogué, R, Sala, I, Sánchez-Saudinós, MB, García-Sebastian, M, Villanúa, J, Izagirre, A, Estanga, A, Ecay-Torres, M, Iriondo, A, Clerigue, M, Tainta, M, Pozueta, A, González, A, Martínez-Heras, E, Llufriu, S, Blesa, R, Sanchez-Juan, P, Martínez-Lage, P, Lleó, A & Fortea, J 2018, 'Cortical microstructural changes along the Alzheimer's disease continuum', Alzheimer's and Dementia, vol. 14, no. 3, pp. 340-351. https://doi.org/10.1016/j.jalz.2017.09.013

TY - JOUR

T1 - Cortical microstructural changes along the Alzheimer's disease continuum

AU - Montal, Victor

AU - Vilaplana, Eduard

AU - Alcolea, Daniel

AU - Pegueroles, Jordi

AU - Pasternak, Ofer

AU - González-Ortiz, Sofia

AU - Clarimón, Jordi

AU - Carmona-Iragui, María

AU - Illán-Gala, Ignacio

AU - Morenas-Rodríguez, Estrella

AU - Ribosa-Nogué, Roser

AU - Sala, Isabel

AU - Sánchez-Saudinós, María Belén

AU - García-Sebastian, Maite

AU - Villanúa, Jorge

AU - Izagirre, Andrea

AU - Estanga, Ainara

AU - Ecay-Torres, Mirian

AU - Iriondo, Ane

AU - Clerigue, Montserrat

AU - Tainta, Mikel

AU - Pozueta, Ana

AU - González, Andrea

AU - Martínez-Heras, Eloy

AU - Llufriu, Sara

AU - Blesa, Rafael

AU - Sanchez-Juan, Pascual

AU - Martínez-Lage, Pablo

AU - Lleó, Alberto

AU - Fortea, Juan

PY - 2018/3/1

Y1 - 2018/3/1

N2 - © 2017 the Alzheimer's Association Introduction: Cortical mean diffusivity (MD) and free water fraction (FW) changes are proposed biomarkers for Alzheimer's disease (AD). Methods: We included healthy control subjects (N = 254), mild cognitive impairment (N = 41), and AD dementia (N = 31) patients. Participants underwent a lumbar puncture and a 3 T magnetic resonance imaging. Healthy control subjects were classified following National Institute on Aging-Alzheimer's Association stages (stage 0, N = 220; stage 1, N = 25; and stage 2/3, N = 9). We assessed the cortical MD, cortical FW, and cortical thickness (CTh) changes along the AD continuum. Results: Microstructural and macrostructural changes show a biphasic trajectory. Stage 1 subjects showed increased CTh and decreased MD and FW with respect the stage 0 subjects. Stage 2/3 subjects showed decreased CTh and increased cortical MD and FW, changes that were more widespread in symptomatic stages. Discussion: These results support a biphasic model of changes in AD, which could affect the selection of patients for clinical trials and the use of magnetic resonance imaging as a surrogate marker of disease modification.

AB - © 2017 the Alzheimer's Association Introduction: Cortical mean diffusivity (MD) and free water fraction (FW) changes are proposed biomarkers for Alzheimer's disease (AD). Methods: We included healthy control subjects (N = 254), mild cognitive impairment (N = 41), and AD dementia (N = 31) patients. Participants underwent a lumbar puncture and a 3 T magnetic resonance imaging. Healthy control subjects were classified following National Institute on Aging-Alzheimer's Association stages (stage 0, N = 220; stage 1, N = 25; and stage 2/3, N = 9). We assessed the cortical MD, cortical FW, and cortical thickness (CTh) changes along the AD continuum. Results: Microstructural and macrostructural changes show a biphasic trajectory. Stage 1 subjects showed increased CTh and decreased MD and FW with respect the stage 0 subjects. Stage 2/3 subjects showed decreased CTh and increased cortical MD and FW, changes that were more widespread in symptomatic stages. Discussion: These results support a biphasic model of changes in AD, which could affect the selection of patients for clinical trials and the use of magnetic resonance imaging as a surrogate marker of disease modification.

KW - Alzheimer's disease continuum

KW - Amyloid

KW - Biomarkers

KW - CSF

KW - Cortical microstructure

KW - MRI

KW - Tau

U2 - 10.1016/j.jalz.2017.09.013

DO - 10.1016/j.jalz.2017.09.013

M3 - Article

VL - 14

SP - 340

EP - 351

IS - 3

ER -

Cortical microstructural changes along the Alzheimer's disease continuum

Abstract

Keywords

Access to Document

Fingerprint

Cite this