Correlation of inflammatory and cardiovascular biomarkers with pneumonia severity scores

Alicia Lacoma, Albert Bas, Pere Tudela, Montse Giménez, Josep Maria Mòdol, Miguel Pérez, Vicente Ausina, Jose Dominguez, Cristina Prat-Aymerich

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7 Citations (Scopus)

Abstract

Purpose To assess the correlation of procalcitonin (PCT), C-reactive protein (CRP), neopterin, mid-regional pro-atrial natriuretic peptide (MR-proANP), and mid-regional pro-adrenomedullin (MR-proADM) with severity risk scores: severe CAP (SCAP) and SMART-COP in patients with community-acquired pneumonia (CAP), as well as short term prognosis and to determine the correlation with mortality risk scores. Methods Eighty-five patients with a final diagnosis of pneumonia were consecutively included during a two month period. Epidemiological, clinical, microbiological, and radiological data were recorded. Patients were stratified according to the PSI, CURB-65, SCAP and SMART-COP. Complications were defined as respiratory failure/shock, need of ICU, and death. Plasma samples were collected at admission. Results MR-proANP and MR-proADM showed significantly higher levels in high risk SCAP group in comparison to low risk. When considering SMART-COP none of the biomarkers showed statistical differences. MR-proADM levels were high in patients with high risk of needing intensive respiratory or vasopressor support according to SMRT-CO. Neopterin and MR-proADM were significantly higher in patients that developed complications. PCT and MR-proADM showed significantly higher levels in cases of a definite bacterial diagnosis in comparison to probable bacterial, and unknown origin. MR-proANP and MR-proADM levels increased statistically according to PSI and CURB-65. Conclusions Biomarker levels are higher in pneumonia patients with a poorer prognosis according to SCAP and SMART-COP indexes, and to the development of complications. © 2013 Elsevier España, S.L. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica.
Original languageEnglish
Pages (from-to)140-146
JournalEnfermedades Infecciosas y Microbiologia Clinica
Volume32
Issue number3
DOIs
Publication statusPublished - 1 Mar 2014

Keywords

  • Biomarkers
  • Pneumonia
  • Prognosis
  • Severity scores

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    Lacoma, A., Bas, A., Tudela, P., Giménez, M., Mòdol, J. M., Pérez, M., Ausina, V., Dominguez, J., & Prat-Aymerich, C. (2014). Correlation of inflammatory and cardiovascular biomarkers with pneumonia severity scores. Enfermedades Infecciosas y Microbiologia Clinica, 32(3), 140-146. https://doi.org/10.1016/j.eimc.2013.07.006