Correlation between clinico-pathological outcome and typing of Haemophilus parasuis field strains

Virginia Aragon, Marta Cerdà-Cuéllar, Lorenzo Fraile, Mark Mombarg, Miquel Nofrarías, Alexandre Olvera, Marina Sibila, David Solanes, Joaquim Segalés

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50 Citations (Scopus)


Haemophilus parasuis is the etiologic agent of Glässer's disease in pigs, which is pathologically characterized by serofibrinous polyserositis and arthritis. H. parasuis include virulent and non-virulent strains and confirmation of virulence in H. parasuis is still dependent on experimental reproduction of the disease. Since the variability in virulence is supported by serotyping and genotyping (particularly, multilocus sequence typing [MLST]), we examined the relationship between the classification of 8 field strains by these methods and their capacity to cause disease in snatch-farrowed, colostrum-deprived piglets. The severity of clinical signs and lesions produced by the different strains correlated with the quantity of H. parasuis recovered from the lesions. However, the virulence of the strains in the animal model did not show a total correlation with their serovar or their classification by MLST. More studies are needed to identify a virulence marker that could substitute animal experimentation in H. parasuis. In addition, we reproduced disease in domestic pigs with a strain isolated from the nasal cavity of wild boars. This result indicates the existence of virulent strains of H. parasuis in wild suids, which could produce disease under appropriate circumstances, and suggests a possible source of infection for domestic pigs. © 2009 Elsevier B.V.
Original languageEnglish
Pages (from-to)387-393
JournalVeterinary Microbiology
Publication statusPublished - 1 May 2010


  • Animal model
  • Field strains
  • Glässer's disease
  • Haemophilus parasuis
  • Wild boar


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