TY - JOUR
T1 - Copper(II) complexes of the antihypertensive drug nadolol
AU - Getova, Valentina T.
AU - Pantcheva, Ivayla N.
AU - Ivanov, Darvin S.
AU - Mehandjiev, Dimitar R.
AU - Skumryev, Vassil
AU - Bontchev, Panayot R.
PY - 2007/3/1
Y1 - 2007/3/1
N2 - The complexation of the non-selective β-blocker nadolol, HL, 1 with copper(II) leads to format ion of mono-and dinuclear complexes depending mainly on the metal-to-ligand molar ratio. The mononuclear violet complex CuL22Solv, 2, was obtained in a soluble form at metal-to-ligand molar ratio Cu(II): HL ≤ 1: 10 in methanolic or slightly alkaline aqueous solutions. The dinuclear green complex Cu2L2Cl2H2O, 3 was synthesized at Cu(II): HL ≥ 1: 2 molar ratio in methanolic solutions. The complexes were studied using spectral (UV-Vis, FT-IR, EPR), magnetochemical, thermogravimetric methods and elemental analysis. In the complexes nadolol acts as a monoanionic bidentate ligand coordinated to copper(II) through the NH-and the deprotonated OH-groups of its aminoalcohol fragment. © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2006.
AB - The complexation of the non-selective β-blocker nadolol, HL, 1 with copper(II) leads to format ion of mono-and dinuclear complexes depending mainly on the metal-to-ligand molar ratio. The mononuclear violet complex CuL22Solv, 2, was obtained in a soluble form at metal-to-ligand molar ratio Cu(II): HL ≤ 1: 10 in methanolic or slightly alkaline aqueous solutions. The dinuclear green complex Cu2L2Cl2H2O, 3 was synthesized at Cu(II): HL ≥ 1: 2 molar ratio in methanolic solutions. The complexes were studied using spectral (UV-Vis, FT-IR, EPR), magnetochemical, thermogravimetric methods and elemental analysis. In the complexes nadolol acts as a monoanionic bidentate ligand coordinated to copper(II) through the NH-and the deprotonated OH-groups of its aminoalcohol fragment. © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2006.
KW - Copper(II) complexes
KW - Nadolol
KW - β-blocker
U2 - https://doi.org/10.2478/s11532-006-0070-9
DO - https://doi.org/10.2478/s11532-006-0070-9
M3 - Article
VL - 5
SP - 118
EP - 131
ER -