Copper(II) complexes of the antihypertensive drug nadolol

Valentina T. Getova, Ivayla N. Pantcheva, Darvin S. Ivanov, Dimitar R. Mehandjiev, Vassil Skumryev, Panayot R. Bontchev

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

The complexation of the non-selective β-blocker nadolol, HL, 1 with copper(II) leads to format ion of mono-and dinuclear complexes depending mainly on the metal-to-ligand molar ratio. The mononuclear violet complex CuL22Solv, 2, was obtained in a soluble form at metal-to-ligand molar ratio Cu(II): HL ≤ 1: 10 in methanolic or slightly alkaline aqueous solutions. The dinuclear green complex Cu2L2Cl2H2O, 3 was synthesized at Cu(II): HL ≥ 1: 2 molar ratio in methanolic solutions. The complexes were studied using spectral (UV-Vis, FT-IR, EPR), magnetochemical, thermogravimetric methods and elemental analysis. In the complexes nadolol acts as a monoanionic bidentate ligand coordinated to copper(II) through the NH-and the deprotonated OH-groups of its aminoalcohol fragment. © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2006.
Original languageEnglish
Pages (from-to)118-131
JournalCentral European Journal of Chemistry
Volume5
DOIs
Publication statusPublished - 1 Mar 2007

Keywords

  • Copper(II) complexes
  • Nadolol
  • β-blocker

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