Copper(II) complexes of the antihypertensive drug nadolol

Valentina T. Getova; Ivayla N. Pantcheva; Darvin S. Ivanov; Dimitar R. Mehandjiev; Vassil Skumryev; Panayot R. Bontchev

doi:https://doi.org/10.2478/s11532-006-0070-9

Copper(II) complexes of the antihypertensive drug nadolol

Valentina T. Getova, Ivayla N. Pantcheva, Darvin S. Ivanov, Dimitar R. Mehandjiev, Vassil Skumryev, Panayot R. Bontchev

Department of Physics

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

The complexation of the non-selective β-blocker nadolol, HL, 1 with copper(II) leads to format ion of mono-and dinuclear complexes depending mainly on the metal-to-ligand molar ratio. The mononuclear violet complex CuL22Solv, 2, was obtained in a soluble form at metal-to-ligand molar ratio Cu(II): HL ≤ 1: 10 in methanolic or slightly alkaline aqueous solutions. The dinuclear green complex Cu2L2Cl2H2O, 3 was synthesized at Cu(II): HL ≥ 1: 2 molar ratio in methanolic solutions. The complexes were studied using spectral (UV-Vis, FT-IR, EPR), magnetochemical, thermogravimetric methods and elemental analysis. In the complexes nadolol acts as a monoanionic bidentate ligand coordinated to copper(II) through the NH-and the deprotonated OH-groups of its aminoalcohol fragment. © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2006.

Original language	English
Pages (from-to)	118-131
Journal	Central European Journal of Chemistry
Volume	5
DOIs	https://doi.org/10.2478/s11532-006-0070-9
Publication status	Published - 1 Mar 2007

Keywords

Copper(II) complexes
Nadolol
β-blocker

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@article{b36a77bde7f04cf98e57c223f1c34024,

title = "Copper(II) complexes of the antihypertensive drug nadolol",

abstract = "The complexation of the non-selective β-blocker nadolol, HL, 1 with copper(II) leads to format ion of mono-and dinuclear complexes depending mainly on the metal-to-ligand molar ratio. The mononuclear violet complex CuL22Solv, 2, was obtained in a soluble form at metal-to-ligand molar ratio Cu(II): HL ≤ 1: 10 in methanolic or slightly alkaline aqueous solutions. The dinuclear green complex Cu2L2Cl2H2O, 3 was synthesized at Cu(II): HL ≥ 1: 2 molar ratio in methanolic solutions. The complexes were studied using spectral (UV-Vis, FT-IR, EPR), magnetochemical, thermogravimetric methods and elemental analysis. In the complexes nadolol acts as a monoanionic bidentate ligand coordinated to copper(II) through the NH-and the deprotonated OH-groups of its aminoalcohol fragment. {\textcopyright} Versita Warsaw and Springer-Verlag Berlin Heidelberg 2006.",

keywords = "Copper(II) complexes, Nadolol, β-blocker",

author = "Getova, {Valentina T.} and Pantcheva, {Ivayla N.} and Ivanov, {Darvin S.} and Mehandjiev, {Dimitar R.} and Vassil Skumryev and Bontchev, {Panayot R.}",

year = "2007",

month = mar,

day = "1",

doi = "https://doi.org/10.2478/s11532-006-0070-9",

language = "English",

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pages = "118--131",

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TY - JOUR

T1 - Copper(II) complexes of the antihypertensive drug nadolol

AU - Getova, Valentina T.

AU - Pantcheva, Ivayla N.

AU - Ivanov, Darvin S.

AU - Mehandjiev, Dimitar R.

AU - Skumryev, Vassil

AU - Bontchev, Panayot R.

PY - 2007/3/1

Y1 - 2007/3/1

N2 - The complexation of the non-selective β-blocker nadolol, HL, 1 with copper(II) leads to format ion of mono-and dinuclear complexes depending mainly on the metal-to-ligand molar ratio. The mononuclear violet complex CuL22Solv, 2, was obtained in a soluble form at metal-to-ligand molar ratio Cu(II): HL ≤ 1: 10 in methanolic or slightly alkaline aqueous solutions. The dinuclear green complex Cu2L2Cl2H2O, 3 was synthesized at Cu(II): HL ≥ 1: 2 molar ratio in methanolic solutions. The complexes were studied using spectral (UV-Vis, FT-IR, EPR), magnetochemical, thermogravimetric methods and elemental analysis. In the complexes nadolol acts as a monoanionic bidentate ligand coordinated to copper(II) through the NH-and the deprotonated OH-groups of its aminoalcohol fragment. © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2006.

AB - The complexation of the non-selective β-blocker nadolol, HL, 1 with copper(II) leads to format ion of mono-and dinuclear complexes depending mainly on the metal-to-ligand molar ratio. The mononuclear violet complex CuL22Solv, 2, was obtained in a soluble form at metal-to-ligand molar ratio Cu(II): HL ≤ 1: 10 in methanolic or slightly alkaline aqueous solutions. The dinuclear green complex Cu2L2Cl2H2O, 3 was synthesized at Cu(II): HL ≥ 1: 2 molar ratio in methanolic solutions. The complexes were studied using spectral (UV-Vis, FT-IR, EPR), magnetochemical, thermogravimetric methods and elemental analysis. In the complexes nadolol acts as a monoanionic bidentate ligand coordinated to copper(II) through the NH-and the deprotonated OH-groups of its aminoalcohol fragment. © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2006.

KW - Copper(II) complexes

KW - Nadolol

KW - β-blocker

U2 - https://doi.org/10.2478/s11532-006-0070-9

DO - https://doi.org/10.2478/s11532-006-0070-9

M3 - Article

VL - 5

SP - 118

EP - 131

ER -