TY - JOUR
T1 - Copper protection in the palladium catalyzed regioselective allylation of a model polyketide: Methyl 3,5-dioxohexanoate
AU - Marquet, Jorge
AU - Moreno-Mañas, Marcial
AU - Prat, María
PY - 1989/1/1
Y1 - 1989/1/1
N2 - Regioselective allylation of the model polyketide system methyl 3,5-dioxohexanoate at the C-2 position can be accomplished even with secondary and tertiary radicals by palladium catalyzed allylation of its copper(II) complex, 1a. Initial results indicate that the cobalt(II) complex, 1b, can be also useful. Cyclizations of the resulting diketoesters, 3, afford triacetic acid lactone derivatives, 5, regioselectively allylated at C-3. © 1989.
AB - Regioselective allylation of the model polyketide system methyl 3,5-dioxohexanoate at the C-2 position can be accomplished even with secondary and tertiary radicals by palladium catalyzed allylation of its copper(II) complex, 1a. Initial results indicate that the cobalt(II) complex, 1b, can be also useful. Cyclizations of the resulting diketoesters, 3, afford triacetic acid lactone derivatives, 5, regioselectively allylated at C-3. © 1989.
U2 - 10.1016/S0040-4039(00)99414-0
DO - 10.1016/S0040-4039(00)99414-0
M3 - Article
VL - 30
SP - 3105
EP - 3108
IS - 23
ER -