Copper protection in the palladium catalyzed regioselective allylation of a model polyketide: Methyl 3,5-dioxohexanoate

Jorge Marquet, Marcial Moreno-Mañas, María Prat

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

Regioselective allylation of the model polyketide system methyl 3,5-dioxohexanoate at the C-2 position can be accomplished even with secondary and tertiary radicals by palladium catalyzed allylation of its copper(II) complex, 1a. Initial results indicate that the cobalt(II) complex, 1b, can be also useful. Cyclizations of the resulting diketoesters, 3, afford triacetic acid lactone derivatives, 5, regioselectively allylated at C-3. © 1989.
Original languageEnglish
Pages (from-to)3105-3108
JournalTetrahedron Letters
Volume30
Issue number23
DOIs
Publication statusPublished - 1 Jan 1989

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