Copper complex protection in the regioselective alkylation of methyl 3,5-dioxohexanoate. Preparation of 3-alkyl derivatives of 4-hydroxy-6-methyl-2-pyrone

Jordi Cervello, Jorge Marquet, Marcial Moreno-Mañas

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10 Citations (Scopus)

Abstract

Protection of the diketone moiety of the polyketide model methyl 3,5-dioxohexanoate by copper(II) complex formation followed by alkylation of the free C-2 position results in overall regioselective alkylation of the diketoester to afford methyl 2-alkyl-3,5-dioxohexanoates, which under cyclization afford 3-alkyl derivatives of triacetic acid lactone. © 1987.
Original languageEnglish
Pages (from-to)3715-3716
JournalTetrahedron Letters
Volume28
Issue number32
DOIs
Publication statusPublished - 1 Jan 1987

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