Protection of the diketone moiety of the polyketide model methyl 3,5-dioxohexanoate by copper(II) complex formation followed by alkylation of the free C-2 position results in overall regioselective alkylation of the diketoester to afford methyl 2-alkyl-3,5-dioxohexanoates, which under cyclization afford 3-alkyl derivatives of triacetic acid lactone. © 1987.
|Publication status||Published - 1 Jan 1987|
Cervello, J., Marquet, J., & Moreno-Mañas, M. (1987). Copper complex protection in the regioselective alkylation of methyl 3,5-dioxohexanoate. Preparation of 3-alkyl derivatives of 4-hydroxy-6-methyl-2-pyrone. Tetrahedron Letters, 28(32), 3715-3716. https://doi.org/10.1016/S0040-4039(00)96365-2